Rha Min-Seok, Kim A Reum, Shin Eui-Cheol
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
The Center for Epidemic Preparedness, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Immune Netw. 2021 Feb 17;21(1):e2. doi: 10.4110/in.2021.21.e2. eCollection 2021 Feb.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4 and CD8 T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染会引发2019冠状病毒病（COVID-19），这是一种仍在流行的疾病。在当前的综述中，我们描述了急性和康复期COVID-19患者中针对SARS-CoV-2的CD4和CD8 T细胞反应。我们还讨论了COVID-19严重程度与针对SARS-CoV-2的T细胞反应之间的关系，并总结了关于未接触过SARS-CoV-2的个体中SARS-CoV-2反应性T细胞的最新报告。这些T细胞可能是由先前感染人类普通感冒冠状病毒而引发的交叉反应性细胞。最后，我们概述了在疫苗接种背景下针对SARS-CoV-2的T细胞反应。为了开发有效的疫苗和治疗方法，需要更好地了解针对SARS-CoV-2的T细胞反应。
