Chakraborty Chiranjib, Sharma Ashish Ranjan, Bhattacharya Manojit, Sharma Garima, Saha Rudra P, Lee Sang-Soo
Department of Biotechnology, School of Life Science & Biotechnology, Adamas University, Kolkata 700126, India.
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea.
Immune Netw. 2021 Jan 19;21(1):e5. doi: 10.4110/in.2021.21.e5. eCollection 2021 Feb.
Coronavirus disease 2019 (COVID-19) has developed as a pandemic, and it created an outrageous effect on the current healthcare and economic system throughout the globe. To date, there is no appropriate therapeutics or vaccines against the disease. The entire human race is eagerly waiting for the development of new therapeutics or vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Efforts are being taken to develop vaccines at a rapid rate for fighting against the ongoing pandemic situation. Amongst the various vaccines under consideration, some are either in the preclinical stage or in the clinical stages of development (phase-I, -II, and -III). Even, phase-III trials are being conducted for some repurposed vaccines like Bacillus Calmette-Guérin, polio vaccine, and measles-mumps-rubella. We have highlighted the ongoing clinical trial landscape of the COVID-19 as well as repurposed vaccines. An insight into the current status of the available antigenic epitopes for SARS-CoV-2 and different types of vaccine platforms of COVID-19 vaccines has been discussed. These vaccines are highlighted throughout the world by different news agencies. Moreover, ongoing clinical trials for repurposed vaccines for COVID-19 and critical factors associated with the development of COVID-19 vaccines have also been described.
2019冠状病毒病（COVID-19）已发展成为一场大流行疾病，对全球当前的医疗保健和经济体系产生了极大影响。迄今为止，尚无针对该疾病的合适治疗方法或疫苗。全人类都在热切等待针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的新治疗方法或疫苗的研发。目前正在努力快速研发疫苗以应对当前的大流行形势。在正在考虑的各种疫苗中，有些处于临床前阶段或处于研发的临床阶段（I期、II期和III期）。甚至，正在对一些重新利用的疫苗进行III期试验，如卡介苗、脊髓灰质炎疫苗和麻疹-腮腺炎-风疹疫苗。我们重点介绍了COVID-19以及重新利用疫苗的当前临床试验情况。本文还讨论了对SARS-CoV-2可用抗原表位的现状以及COVID-19疫苗不同类型疫苗平台的见解。这些疫苗受到了不同新闻机构在全球范围内的关注。此外，还描述了针对COVID-19重新利用疫苗的正在进行的临床试验以及与COVID-19疫苗研发相关的关键因素。
