长链非编码RNA作为妊娠肝内胆汁淤积症潜在新型生物标志物的诊断和预后价值
Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy.
作者信息
Zou Shaohan, Zhao Shaojie, Wang Jing, Dong Ruirui, Zou Ping, Liang Fengbing, Zhu Ting Ting, Zhou Tao, Li Na, Zhang Yan, Wang Tiejun, Chen Minjian, Zhou Conghua, Zhang Ting, Luo Liang
机构信息
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou 310000, China.
The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China.
出版信息
Biomed Res Int. 2021 Feb 27;2021:8858326. doi: 10.1155/2021/8858326. eCollection 2021.
Long noncoding RNAs (lncRNAs) are a class of important regulators participating in various pathological processes. Until now, the role of lncRNAs in the occurrence and development of intrahepatic cholestasis of pregnancy (ICP) has rarely been investigated. The data from microarray screening revealed 58 upregulated and 85 downregulated lncRNAs and 47 upregulated and 71 downregulated mRNAs in ICP patients compared to healthy controls. Bioinformatics analysis revealed biological processes focused on lipid metabolism, apoptosis, cell cycle, cell differentiation, and oxidative stress. Furthermore, the expressions of three lncRNAs (ENST00000505175.1, ASO3480, and ENST00000449605.1) chosen for verification were significantly decreased and showed the diagnostic and prognostic value for ICP based on ROC analysis. This is the first study to report the specific role of lncRNAs in ICP, which may be helpful for the diagnosis and prognosis of ICP clinically.
长链非编码RNA（lncRNAs）是一类参与各种病理过程的重要调节因子。迄今为止，lncRNAs在妊娠期肝内胆汁淤积症（ICP）发生发展中的作用鲜有研究。与健康对照相比，来自微阵列筛选的数据显示，ICP患者中有58个lncRNAs上调，85个lncRNAs下调，47个mRNA上调，71个mRNA下调。生物信息学分析揭示了聚焦于脂质代谢、细胞凋亡、细胞周期、细胞分化和氧化应激的生物学过程。此外，经选择用于验证的3个lncRNAs（ENST00000505175.1、ASO3480和ENST00000449605.1）的表达显著降低，基于ROC分析显示出对ICP的诊断和预后价值。这是首次报道lncRNAs在ICP中具体作用的研究，可能有助于临床上ICP的诊断和预后判断。
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