Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China.
Biomed Res Int. 2021 Feb 26;2021:8863637. doi: 10.1155/2021/8863637. eCollection 2021.
To investigate the levels of transforming growth factor- (TGF-) in human aqueous humor (AH) and plasma (PL) of patients with myopia, and verify whether there is an association between these levels and their association with axial length (AL).
Thirty-eight myopic patients who received intraocular collamer lens (ICL) implantation were enrolled in this cross-sectional study. Patients were divided into three groups based on AL with cut-off points of 26 and 28 mm. AH and PL samples were obtained during ICL implantation surgery. The levels of TGF-1, TGF-2, and TGF-3 in the AH and PL samples were measured using Luminex xMAP Technology kits (Milliplex xMAP kits). The protein levels of TGF-s in both AH and PL samples and their relationships with AL were analyzed.
In all, 38 patients (59 eyes) were enrolled and divided into the three groups: group A contained 7 people (10 eyes), group B contained 22 people (37 eyes), and group C contained 9 people (12 eyes). In the AH group, we detected TGF-1 ( : 19.97 pg/mL), TGF-2 (2446.00 pg/mL), and TGF-3 (26.33 pg/mL); in PL, these concentrations were 8984.00, 523.44, and 210.47 pg/mL, respectively. The levels of TGF-1 and TGF-3 in AH were positively associated with AL. None of the three isoforms in PL were related to those in AH or to AL.
The levels of TGF-1 and TGF-3 in AH were more strongly associated with the severity of myopia than the types of TGF- in PL.
研究人眼房水（AH）和血浆（PL）中转化生长因子-（TGF-）的水平，验证这些水平是否与近视患者的眼轴长度（AL）有关。
本横断面研究纳入了 38 名接受眼内 collamer 透镜（ICL）植入术的近视患者。根据 AL 将患者分为三组，截断值为 26 和 28mm。在 ICL 植入手术期间采集 AH 和 PL 样本。使用 Luminex xMAP 技术试剂盒（Milliplex xMAP 试剂盒）测量 AH 和 PL 样本中 TGF-1、TGF-2 和 TGF-3 的水平。分析了 AH 和 PL 样本中 TGF-s 的蛋白水平及其与 AL 的关系。
共纳入 38 名患者（59 只眼），分为三组：A 组 7 人（10 只眼），B 组 22 人（37 只眼），C 组 9 人（12 只眼）。在 AH 组中，我们检测到 TGF-1（：19.97pg/mL）、TGF-2（2446.00pg/mL）和 TGF-3（26.33pg/mL）；PL 中的浓度分别为 8984.00、523.44 和 210.47pg/mL。AH 中 TGF-1 和 TGF-3 的水平与 AL 呈正相关。PL 中的三种同工型均与 AH 或 AL 无关。
与 PL 中的 TGF-类型相比，AH 中 TGF-1 和 TGF-3 的水平与近视的严重程度更相关。
