Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Northwestern Polytechnical University, Xi'an, 710004, Shaanxi, China.
Department of Ophthalmology, University of Heidelberg, 69120, Heidelberg, Germany.
Sci Rep. 2022 Oct 26;12(1):17974. doi: 10.1038/s41598-022-22746-4.
Transforming growth factor-β (TGF-β) is the critical regulator of physiological and pathological conditions in lens. The TGF-β signaling pathway is closely associated with high myopia patients. Thirty eyes from fifteen patients with high myopia who received sequential cataract surgery were enrolled in this prospective study. Ten cataract patients with non-myopia were chosen as a control group. Aqueous humor (AH) samples were used to detect the levels of TGF-β1, TGF-β2, and TGF-β3 in both groups. Compared with the non-myopic cataracts patient group, the highly myopic cataracts group had a significantly higher TGF-β2 (P = 0.019). Besides, the level of TGF-β2 of the second eye was significantly higher than that in the first eye in high myopia cataract patients group (P = 0.037). And TGF-β1 showed significant differences with age and axial length of high myopia cataract patients. Therefore, TGF-β2 may contribute to the development of high myopia and cataract surgery increased the expression of TGF-β2.
转化生长因子-β（TGF-β）是晶状体生理和病理状态的关键调节因子。TGF-β 信号通路与高度近视患者密切相关。本前瞻性研究纳入了 15 名接受序贯白内障手术的高度近视患者的 30 只眼。选择 10 名非近视白内障患者作为对照组。两组均采用房水样本检测 TGF-β1、TGF-β2 和 TGF-β3 水平。与非近视白内障患者组相比，高度近视白内障组 TGF-β2 水平显著升高（P=0.019）。此外，高度近视白内障患者组中第二只眼的 TGF-β2 水平明显高于第一只眼（P=0.037）。并且 TGF-β1 与高度近视白内障患者的年龄和眼轴长度有显著差异。因此，TGF-β2 可能有助于高度近视的发展，白内障手术增加了 TGF-β2 的表达。
