Jia Yan, Hu Dan-Ning, Zhou Jibo
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.
Departments of Ophthalmology and Pathology, New York Eye and Ear Infirmary, New York, NY 10003, USA.
Biomed Res Int. 2014;2014:258591. doi: 10.1155/2014/258591. Epub 2014 May 20.
To analyze the relationship between transforming growth factor-beta 2 (TGF- β 2) levels in the anterior chamber aqueous humor and axial length of patients with myopia.
TGF- β 2 was measured with the Luminex xMAP Technology by using commercially available Milliplex xMAP Kits. Sixty-five aqueous humor samples were collected during cataract or clear lens extraction surgery and TGF- β 2 levels in these specimens were analyzed. According to the axial length, the samples were divided into three groups: A (AL ≤ 24 mm), B (24 ~ 29 mm), and C (AL ≥ 29 mm).
Aqueous humor samples were analyzed from subjects with an average age of 67.0 ± 11.7 years. Mean TGF- β 2 concentration of all aqueous samples was 422.2 ± 258.8 pg/mL. TGF- β 2 concentration in group C (543 ± 317 pg/mL) was significantly greater than that in group A (390 ± 212 pg/mL) and group B (337 ± 217 pg/mL). The concentration of TGF- β 2 was positively correlated with axial length (r = 0.308, P = 0.013).
TGF- β 2 is likely to be acting as a critical factor in axial elongation and development of myopia.
分析近视患者前房房水中转化生长因子-β2（TGF-β2）水平与眼轴长度之间的关系。
采用Luminex xMAP技术，使用市售的Milliplex xMAP试剂盒检测TGF-β2。在白内障或透明晶状体摘除手术期间收集65份房水样本，并分析这些样本中的TGF-β2水平。根据眼轴长度，将样本分为三组：A组（眼轴长度≤24mm）、B组（24~29mm）和C组（眼轴长度≥29mm）。
对平均年龄为67.0±11.7岁的受试者的房水样本进行分析。所有房水样本的平均TGF-β2浓度为422.2±258.8pg/mL。C组的TGF-β2浓度（543±317pg/mL）显著高于A组（390±212pg/mL）和B组（337±217pg/mL）。TGF-β2浓度与眼轴长度呈正相关（r=0.308，P=0.013）。
TGF-β2可能是近视眼轴伸长和发展的关键因素。
