[Immunoreactive insulin level in the blood and the blast transformation reaction to insulin and the pancreatic tissue at the initial stages of diabetes mellitus].

The following was examined in 60 adult persons with normal weight and obesity: insulin level during the glucose tolerance test and lymphocyte sensitization to insulin and the pancreas tissue. An increased insulin level both on fasting stomach and after glucose tolerance was noted in obese persons. A delayed elevation of insulin level, particularly in combination of obesity with deranged glucose tolerance was often seen. Immunological reactions to insulin and the pancreatic tissue were mostly noted in patients with moderate obesity and at the initial stage of the carbohydrate metabolism deragement. Lymphocyte sensitization to insulin was characteristic of cases when the glucose was flat, insulin secretion--moderately elevated and insulin/glucose index--increased.