Melnikov M V, Pashenkov M V, Boyko A N
Federal Center of Brain Research and Neurotechnology, Moscow, Russia.
National Research Center Institute of Immunology, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(2):67-70. doi: 10.17116/jnevro202112102167.
Dopamine is a direct mediator of neuroimmune interactions. Recent studies show that by acting on the dopaminergic receptors, it is possible to modulate Th17-immune response, which play a crucial role in the pathogenesis of multiple sclerosis. Dopamine can modulate Th17 cells function as well as dendritic cell-mediated Th17-immune response that allows considering dopaminergic receptors as a new therapeutic target in multiple sclerosis. In this short communication, the prospects of using dopaminergic therapy as a pathogenetic treatment for multiple sclerosis are discussed.
多巴胺是神经免疫相互作用的直接介质。最近的研究表明，通过作用于多巴胺能受体，可以调节在多发性硬化症发病机制中起关键作用的Th17免疫反应。多巴胺可以调节Th17细胞的功能以及树突状细胞介导的Th17免疫反应，这使得多巴胺能受体被视为多发性硬化症的一个新的治疗靶点。在这篇简短的通讯中，讨论了使用多巴胺能疗法作为多发性硬化症致病治疗方法的前景。
