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探索精神分裂症合并抑郁障碍患者视觉障碍的皮质病理生理学——来自小鼠模型的证据。

Exploration of the cortical pathophysiology underlying visual disturbances in schizophrenia comorbid with depressive disorder-An evidence from mouse model.

机构信息

Laboratory of Psychiatric-Neuroimaging-Genetic and Cor-morbidity (PNGC_Lab), Tianjin Anding Hospital, Mental Health Centre of Tianjin, Affiliated Teaching Hospital of Tianjin Medical University, Tianjin, China.

Department of Psychiatry, Wenzhou Seventh Peoples Hospital, Wenzhou, China.

出版信息

Brain Behav. 2021 May;11(5):e02113. doi: 10.1002/brb3.2113. Epub 2021 Mar 17.

DOI:10.1002/brb3.2113
PMID:33729680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8119859/
Abstract

INTRODUCTION

Patients with schizophrenia frequently present with visual disturbances including hallucination, and this symptom is particularly prevalent in individuals with comorbid depressive disorders. Currently, little is known about the neurobiological mechanisms of such psychiatric symptoms, and few explanations for the co-occurrence of schizophrenia, depression, and visual disturbances are available.

METHODS

In this study, we generated a mouse schizophrenia model in which depressive symptoms were also induced. We adopted in vivo two-photon calcium imaging and ex vivo electrophysiological recording of the primary visual cortex to reveal the synaptic transmission and neural activity in the mouse schizophrenia model.

RESULTS

In vivo two-photon calcium imaging and ex vivo electrophysiological recording of the primary visual cortex revealed impaired synaptic transmission and abnormal neural activity in the schizophrenia model, but not in the depression model. These functional deficits were most prominent in the combined schizophrenia and depression model.

CONCLUSION

Overall, our data support a mechanism by which the visual cortex plays a role in visual disturbances in schizophrenia.

摘要

简介

精神分裂症患者常出现视觉障碍，包括幻觉，而这种症状在伴有抑郁障碍的个体中更为常见。目前，人们对这种精神症状的神经生物学机制知之甚少，也很少有解释说明精神分裂症、抑郁症和视觉障碍同时发生的原因。

方法

本研究构建了一种可诱导抑郁症状的精神分裂症小鼠模型。我们采用活体双光子钙成像和离体脑片电生理记录的方法，揭示了精神分裂症模型中小鼠初级视皮层的突触传递和神经活动。

结果

活体双光子钙成像和离体脑片电生理记录显示，精神分裂症模型中存在突触传递受损和神经活动异常，但在抑郁模型中没有。在精神分裂症合并抑郁模型中，这些功能缺陷最为明显。

结论

总之，我们的数据支持了视觉皮层在精神分裂症视觉障碍中的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/32b9902cde14/BRB3-11-e02113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/5a4a50598f1f/BRB3-11-e02113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/73b76ff2f160/BRB3-11-e02113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/1a67becd9099/BRB3-11-e02113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/32b9902cde14/BRB3-11-e02113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/5a4a50598f1f/BRB3-11-e02113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/73b76ff2f160/BRB3-11-e02113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/1a67becd9099/BRB3-11-e02113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e92/8119859/32b9902cde14/BRB3-11-e02113-g005.jpg

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