Department of Genetics, Cell Biology and Development, University of Minnesota, 420 Washington Ave SE, Minneapolis, MN, 55455, USA.
Adv Biol (Weinh). 2021 Mar;5(3):e2000188. doi: 10.1002/adbi.202000188. Epub 2021 Feb 7.
Building a live cell from non-living building blocks would be a fundamental breakthrough in biological sciences, and it would enable engineering new lineages of life, not directly descendant of the Last Universal Common Ancestor. Fully engineered synthetic cells will have architectures that can be radically different from the natural cells, yet most life processes reconstituted in synthetic cells so far are built from natural and biosimilar building blocks. Most natural processes have already been reconstituted in synthetic cell chassis. This paper summarizes recent advancements in using non-living building blocks to reconstitute some of the most crucial features of living systems in a fully engineerable chassis of a synthetic cell.
从非生命构建模块构建活细胞将是生物科学的一个重大突破，它将使工程新的生命谱系成为可能，而这些生命谱系不是最后一个普遍共同祖先的直接后代。完全工程化的合成细胞将具有与天然细胞截然不同的结构，但迄今为止在合成细胞中重建的大多数生命过程都是由天然和生物相似的构建块构建的。大多数天然过程已经在合成细胞底盘中得到重建。本文总结了利用非生命构建块在完全可工程化的合成细胞底盘中重建生命系统的一些最关键特征的最新进展。
