自下而上的合成生物学：制造人工血小板的模块化设计。
Bottom-up synthetic biology: modular design for making artificial platelets.
作者信息
Majumder Sagardip, Liu Allen P
机构信息
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, United States of America.
出版信息
Phys Biol. 2017 Dec 6;15(1):013001. doi: 10.1088/1478-3975/aa9768.
Abstract
Engineering artificial cells to mimic one or multiple fundamental cell biological functions is an emerging area of synthetic biology. Reconstituting functional modules from biological components in vitro is a challenging yet an important essence of bottom-up synthetic biology. Here we describe the concept of building artificial platelets using bottom-up synthetic biology and the four functional modules that together could enable such an ambitious effort.
摘要
工程化人工细胞以模拟一种或多种基本细胞生物学功能是合成生物学中一个新兴的领域。在体外从生物组件重构功能模块是自下而上合成生物学中一项具有挑战性但又重要的核心任务。在此，我们描述了利用自下而上合成生物学构建人工血小板的概念以及四个功能模块，这四个功能模块共同作用能够推动这一宏伟计划的实现。
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