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俄罗斯圣彼得堡 HIV 阳性且大量饮酒者丙型肝炎连续护理。

The Hepatitis C Continuum of Care Among HIV-Positive Persons with Heavy Alcohol Use in St. Petersburg, Russia.

机构信息

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.

Division of Allergy and Infectious Diseases, Department of Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 9th Ave, Box 359782, Seattle, WA, 98104, USA.

出版信息

AIDS Behav. 2021 Aug;25(8):2533-2541. doi: 10.1007/s10461-021-03214-y. Epub 2021 Mar 17.

Abstract

This study describes the self-reported prevalence of hepatitis C virus (HCV) coinfection and the HCV care continuum among persons enrolled in the St PETER HIV Study, a randomized controlled trial of medications for smoking and alcohol cessation in HIV-positive heavy drinkers and smokers in St. Petersburg, Russia. Baseline health questionnaire data were used to calculate proportions and 95% confidence intervals for self-reported steps along the HCV continuum of care. The cohort included 399 HIV-positive persons, of whom 387 [97.0% (95% CI 95.3-98.7%)] reported a prior HCV test and 315 [78.9% (95% CI 74.9-82.9%)] reported a prior diagnosis of HCV. Among those reporting a diagnosis of HCV, 43 [13.7% (95% CI 9.9-17.4%)] had received treatment for HCV, and 31 [9.8% (95% CI 6.6-13.1%)] had been cured. Despite frequent HCV testing in this HIV-positive Russian cohort, the proportion reporting prior effective HCV treatment was strikingly low. Increased efforts are needed to scale-up HCV treatment among HIV-positive Russians in St. Petersburg.

摘要

本研究描述了圣彼得堡 HIV 研究中,经注册入组的人群中丙型肝炎病毒(HCV)合并感染的自我报告流行率,以及 HCV 关怀延续性的状况。圣彼得堡 HIV 研究是一项随机对照试验,旨在评估针对 HIV 阳性的重度吸烟者和饮酒者的戒烟和戒酒药物。使用基线健康问卷数据,计算沿着 HCV 关怀延续性自我报告步骤的比例和 95%置信区间。该队列纳入了 399 名 HIV 阳性者,其中 387 名(97.0%(95% CI 95.3-98.7%))报告了 HCV 检测史,315 名(78.9%(95% CI 74.9-82.9%))报告了 HCV 诊断史。在报告 HCV 诊断史的人群中,43 名(13.7%(95% CI 9.9-17.4%))接受了 HCV 治疗,31 名(9.8%(95% CI 6.6-13.1%))已被治愈。尽管在这个俄罗斯的 HIV 阳性队列中经常进行 HCV 检测,但报告有效 HCV 治疗的比例却低得惊人。需要加大努力,在圣彼得堡的 HIV 阳性俄罗斯人群中扩大 HCV 治疗。

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