Lei Zhaoxiong, Wu Huiguang, Xiong Yan, Wei Dawei, Wang Xingping, Luoreng Zhuoma, Cai Xiaoyan, Ma Yun
School of Agriculture, Ningxia University, YinChuan, China.
Key Laboratory of Ruminant Molecular and Cellular Breeding, Ningxia University, Ningxia Hui Autonomous Region, YinChuan, China.
Mol Cell Biochem. 2021 Jul;476(7):2837-2845. doi: 10.1007/s11010-021-04132-2. Epub 2021 Mar 17.
Lipid metabolism, which encompasses synthesis and degradation of lipids, is critical for a wide range of cellular functions, including structural and morphological properties of organelles, energy storage, signalling, and the stability and function of membrane proteins. Adipose tissue is a dynamic tissue type that performs a lot of significant physiological functions, including secretion, and is involved in maintaining homeostasis and in regulatory roles of other tissues based on paracrine or endocrine. More recently, several classes of non-coding RNAs (ncRNAs), such as long non-coding RNA (lncRNA), microRNA (miRNA) and circular RNA (circRNA), have been discovered in adipocytes, and they act as critical regulators of gene expression in adipogenesis and regulate adipogenesis through multiple pathways. In the present paper, we discussed several classes of non-coding RNAs and summarized the latest research on the regulatory role of ncRNAs in bovine adipogenesis. We gave examples for known modes of action to look forward to providing reference information future scientific research in cattle breeding.
脂质代谢包括脂质的合成和降解，对多种细胞功能至关重要，包括细胞器的结构和形态特性、能量储存、信号传导以及膜蛋白的稳定性和功能。脂肪组织是一种动态组织类型，具有许多重要的生理功能，包括分泌功能，并通过旁分泌或内分泌参与维持体内稳态以及其他组织的调节作用。最近，在脂肪细胞中发现了几类非编码RNA（ncRNA），如长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（circRNA），它们在脂肪生成过程中作为基因表达的关键调节因子，并通过多种途径调节脂肪生成。在本文中，我们讨论了几类非编码RNA，并总结了ncRNA在牛脂肪生成中调节作用的最新研究。我们给出了已知作用模式的例子，以期为未来牛育种的科学研究提供参考信息。
