Tzameret Military Medical Track, Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.
Department of Obstetrics and Gynecology, Hadassah University Medical Center, Mount Scopus, The Hebrew University, Jerusalem, Israel.
Int J Gynaecol Obstet. 2021 Aug;154(2):285-290. doi: 10.1002/ijgo.13679. Epub 2021 Apr 2.
Cytomegalovirus (CMV) seroconversion in pregnancy is a major health issue with potentially devastating fetal consequences. We opted to determine rates and trends of CMV seroconversion in pregnant army personnel and to isolate risk factors.
In this retrospective cohort study, all pregnancies of army personnel between 2009 and 2019 were evaluated (n = 10 409) and all pregnancies with CMV laboratory records were included. Seroconversion rate was calculated overall and per year. Demographic and obstetrical characteristics were compared between exposed and unexposed women. Independent predictors of seroconversion were further investigated using logistic regression models.
Cytomegalovirus serology status was available in 7665 pregnancies. Seroconversion was evident in 66 women (4.15%) among the seronegative pregnancies. Women in the seroconversion group were significantly more likely to belong to a higher social class. In the regression models, adjusted for age, place of residence, and education, higher parity (adjusted odds ratio [aOR] 2, P < 0.001) and residing in a central district (aOR 2.67, P = 0.002) were significantly associated with seroconversion.
Higher social class appears to be a significant risk factor for CMV seroconversion during pregnancy. Residing in a central district and higher parity appear to be independently associated with an increased risk for seroconversion during pregnancy among army personnel.
巨细胞病毒（CMV）在妊娠期间的血清转化是一个重大的健康问题，可能对胎儿产生毁灭性的后果。我们选择确定妊娠期间军队人员 CMV 血清转化的发生率和趋势，并分离危险因素。
在这项回顾性队列研究中，评估了 2009 年至 2019 年期间所有军队人员的妊娠情况（n=10409），并纳入了所有有 CMV 实验室记录的妊娠。总体和每年计算血清转化率。比较暴露和未暴露妇女的人口统计学和产科特征。使用逻辑回归模型进一步研究血清转化的独立预测因素。
在 7665 例妊娠中获得了 CMV 血清学状态。在 66 例（4.15%）血清阴性妊娠中出现了血清转化。血清转化组的妇女更有可能属于较高的社会阶层。在调整年龄、居住地和教育程度的回归模型中，较高的产次（调整后的优势比[OR]2，P<0.001）和居住在中心区（OR 2.67，P=0.002）与血清转化显著相关。
较高的社会阶层似乎是妊娠期间 CMV 血清转化的一个重要危险因素。居住在中心区和较高的产次似乎与军队人员妊娠期间血清转化的风险增加独立相关。
