Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke-University, Leipziger Straße 44, D-39120, Magdeburg, Germany.
Medical Laboratory for Clinical Chemistry, Microbiology, Infectious Diseases and Genetics "Prof. Schenk/Dr. Ansorge & Colleagues", Schwiesaustraße 11, D-39124, Magdeburg, Germany.
BMC Pregnancy Childbirth. 2023 Apr 28;23(1):299. doi: 10.1186/s12884-023-05612-7.
Congenital cytomegalovirus (CMV) infection is the most common congenital infection worldwide and one of the leading causes of congenital hearing loss in newborns. The aim of this study was to determine the seroprevalence rate for cytomegalovirus in pregnant women and the rate of CMV serological testing utilised during pregnancy in a rural region in Germany.
Retrospective data on the prevalence of CMV IgG and IgM antibodies were obtained from 3,800 women, identified in the study group of 19,511 pregnant women from outpatient settings whose samples were collected between 1 and 2014 and 30 April 2018. In addition, the serological CMV status in regards to various billing methods was further analyzed.
Serological CMV tests were performed in 3,800 (19.5%) out of 19,511 pregnant women. 2,081 (54.8%) of these women were CMV seronegative. Among those, seroconversion rate of 0.37-1.42% was identified. A proportion of 2,710 (14.7%) of all 18,460 women with statutory health insurance made use of the CMV testing as an individual health service.
The low uptake of CMV serological testing in the study population covered indicates low risk awareness among pregnant women and their healthcare professionals. Presented seronegativity rates and routine seroconversion rate, demonstrate importance to improve intervention strategy to prevent feto-maternal CMV transmission.
先天性巨细胞病毒（CMV）感染是全球最常见的先天性感染，也是新生儿先天性听力损失的主要原因之一。本研究旨在确定德国农村地区孕妇巨细胞病毒血清阳性率以及孕期巨细胞病毒血清学检测率。
从 19511 名门诊孕妇的研究组中，回顾性获得了 3800 名妇女的巨细胞病毒 IgG 和 IgM 抗体流行率数据，这些妇女的样本采集于 2014 年 1 月至 2018 年 4 月 30 日。此外，还进一步分析了不同计费方式下的血清巨细胞病毒状态。
在 19511 名孕妇中，有 3800 名（19.5%）进行了血清巨细胞病毒检测。在这些妇女中，2081 名（54.8%）为巨细胞病毒血清阴性。其中，血清转化率为 0.37-1.42%。在所有 18460 名参加法定健康保险的妇女中，有 2710 名（14.7%）人将巨细胞病毒检测作为一项个人健康服务进行了检测。
所涵盖的研究人群中巨细胞病毒血清学检测的低使用率表明孕妇及其医疗保健专业人员的风险意识较低。目前的血清阴性率和常规血清转化率表明，有必要改善干预策略，以预防母婴巨细胞病毒传播。
