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迈向艾滋病毒消除目标的进展:非洲年度艾滋病毒检测和 condom 使用的趋势和预测。

Progress toward HIV elimination goals: trends in and projections of annual HIV testing and condom use in Africa.

机构信息

Graduate School of Public Health, St. Luke's International University, Tokyo.

Department of Obstetrics and Gynaecology, Kanto Rosai Hospital, Kawasaki, Kanagawa, Japan.

出版信息

AIDS. 2021 Jul 1;35(8):1253-1262. doi: 10.1097/QAD.0000000000002870.

Abstract

OBJECTIVES

To estimate trends in and projections of annual HIV testing and condom use at last higher-risk sex and to calculate the probability of reaching key United Nations Programme on AIDS (UNAIDS)'s target.

DESIGN

We included 114 nationally-representative datasets in 38 African countries from Demographic and Health Surveys and Multiple Indicator Cluster Surveys with 1 456 224 sexually active adults age 15-49 from 2003 to 2018.

METHODS

We applied Bayesian mixed effect models to estimate the coverage of annual HIV testing and condom use at last higher-risk sex for every country and year to 2030 and the probability of reaching UNAIDS testing and condom use targets of 95% coverage by 2030.

RESULTS

Seven countries saw downward trends in annual HIV testing and four saw decreases in condom use at higher-risk sex, whereas most countries have upward trends in both indicators. The highest coverage of testing in 2030 is predicted in Swaziland with 92.6% (95% credible interval: 74.5-98.1%), Uganda with 90.5% (72.2-97.2%), and Lesotho with 90.5% (69.4%-97.6%). Meanwhile, Swaziland, Lesotho, and Namibia will have the highest proportion of condom use in 2030 at 85.0% (57.8-96.1%), 75.6% (42.3-93.6%), and 75.5% (42.4-93.2%). The probabilities of reaching targets were very low for both HIV testing (0-28.5%) and condom use (0-12.1%).

CONCLUSIONS

We observed limited progress on annual HIV testing and condom use at last higher-risk sex in Africa and little prospect of reaching global targets for HIV/AIDS elimination. Although some funding agencies are considering withdrawal from supporting Africa, more attention to funding and expanding testing and treatment is needed in this region.

摘要

目的

估计非洲年度艾滋病毒检测和最后一次高危性行为时使用安全套的趋势,并计算达到联合国艾滋病规划署(UNAIDS)关键目标的概率。

设计

我们纳入了来自 38 个非洲国家的 38 个具有全国代表性的数据集,这些数据来自 2003 年至 2018 年的人口与健康调查和多指标类集调查,涵盖了 1456224 名 15-49 岁的性活跃成年人。

方法

我们应用贝叶斯混合效应模型,对每个国家和年份的年度艾滋病毒检测和最后一次高危性行为时使用安全套的覆盖率进行估计,预测至 2030 年,并计算达到 UNAIDS 检测和 2030 年使用安全套覆盖率 95%目标的概率。

结果

7 个国家的年度艾滋病毒检测覆盖率呈下降趋势,4 个国家的高危性行为时使用安全套的比例有所下降,而大多数国家这两个指标都呈上升趋势。2030 年预计检测覆盖率最高的国家是斯威士兰,为 92.6%(95%可信区间:74.5-98.1%),乌干达为 90.5%(72.2-97.2%),莱索托为 90.5%(69.4%-97.6%)。与此同时,斯威士兰、莱索托和纳米比亚将在 2030 年拥有最高的 condom 使用比例,分别为 85.0%(57.8-96.1%)、75.6%(42.3-93.6%)和 75.5%(42.4-93.2%)。达到检测和 condom 使用目标的概率非常低,分别为 0-28.5%和 0-12.1%。

结论

我们观察到非洲在年度艾滋病毒检测和最后一次高危性行为时使用安全套方面进展有限,几乎没有实现全球消除艾滋病毒/艾滋病的目标。尽管一些资金机构正在考虑撤出对非洲的支持,但该地区仍需要更多关注资金投入,扩大检测和治疗。

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