Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Department of Child Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Percept Mot Skills. 2021 Jun;128(3):1091-1106. doi: 10.1177/00315125211002065. Epub 2021 Mar 17.
Children with acute leukemia (ALL) often suffer from several disease and treatment related side-effects during treatment. The aim of the present study was to determine the gross and fine motor functioning and basic cognitive performance of children (n = 25) with ALL who were undergoing induction or consolidation chemotherapy and to compare these characteristics to a normative group (n = 21) of age-matched typically developing children. We assessed the children's motor functions with the Bruininks-Oseretsky Test of Motor Proficiency Second Edition-Short Form and the Nine-hole Peg Test, and we used the Modified Mini-Mental State Exam (MMSE) to evaluate their cognitive performance. Compared to the normative group, children with ALL had lower scores on total motor proficiency and sub-tests scores of motor functions ( < .05), and on the Nine-hole Peg Test performance ( < .05); but their cognitive performance on the MMSE was not significantly different. Children with ALL would likely benefit from structured exercise and rehabilitative interventions during chemotherapy to prevent and/or ameliorate ALL-related motor dysfunction. We also suggest that their cognitive functioning should be further investigated with more extensive well-validated neurocognitive tests for children (e.g., the Wechsler intelligence scales).
患有急性白血病（ALL）的儿童在治疗期间经常会受到多种疾病和治疗相关副作用的影响。本研究旨在确定正在接受诱导或巩固化疗的 ALL 儿童的粗大运动和精细运动功能以及基本认知表现，并将这些特征与年龄匹配的正常发育儿童的参照组（n=21）进行比较。我们使用 Bruininks-Oseretsky 运动能力测试第二版-短式和九孔钉测试评估儿童的运动功能，并用改良的 Mini-Mental State 考试（MMSE）评估他们的认知表现。与参照组相比，ALL 患儿的总运动能力和运动功能的子测试评分较低（<0.05），九孔钉测试表现也较低（<0.05）；但他们在 MMSE 上的认知表现并无显著差异。ALL 患儿在化疗期间可能受益于结构化的运动和康复干预，以预防和/或改善 ALL 相关的运动功能障碍。我们还建议进一步使用更广泛的经过良好验证的儿童神经认知测试（例如韦氏智力量表）来研究他们的认知功能。
