Department of Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey.
Department of Otorhinolaryngology, Faculty of Medicine, Uludag University, Bursa, Turkey.
Tumori. 2022 Apr;108(2):119-124. doi: 10.1177/03008916211001441. Epub 2021 Mar 17.
Lesions mimicking malignancies in the nasopharynx are frequently seen in adult patients. These include inflammatory, metaplastic, and cystic lesions. We aimed to draw attention to rare tumor-like lesions that can be confused with malignancies and cause diagnostic difficulties clinically and radiologically.
A total of 538 patients who underwent nasopharyngeal biopsy in our center between January 2010 and June 2020 were evaluated. Patient information was obtained from patient files and evaluated retrospectively.
A total of 19 of the 538 patients had tumor-like lesions that were included in the study. Granulomatous inflammation was present in seven cases, oncocytic metaplasia in four cases, benign cyst in five cases, fungal infection in two cases, and immunoglobulin G4-related disease in one case.
The nasopharynx is a region where various lesions can be seen. Some lesions form tumor-mimicking mass effect, cause increased thickness, and lead to increased metabolic activity in positron emission tomography-computed tomography that create the illusion of a malignant tumor and histopathologic verification is crucial. We aimed to present these rare tumor-like lesions that should be kept in mind in the differential diagnosis.
在成人患者中，经常会看到类似于恶性肿瘤的鼻咽部病变。这些病变包括炎症性、化生性和囊性病变。我们旨在引起对罕见的肿瘤样病变的关注，这些病变可能与恶性肿瘤混淆，并在临床上和影像学上造成诊断困难。
对 2010 年 1 月至 2020 年 6 月期间在我们中心接受鼻咽活检的 538 例患者进行了评估。从患者档案中获取患者信息并进行回顾性评估。
在 538 例患者中，共有 19 例患者存在肿瘤样病变，这些病变纳入了研究。7 例为肉芽肿性炎症，4 例为嗜酸细胞化生，5 例为良性囊肿，2 例为真菌感染，1 例为 IgG4 相关疾病。
鼻咽是一个可以看到各种病变的区域。一些病变形成肿瘤样肿块效应，导致厚度增加，并导致正电子发射断层扫描-计算机断层扫描（PET-CT）中代谢活性增加，造成恶性肿瘤的假象，因此组织病理学验证至关重要。我们旨在介绍这些在鉴别诊断中应牢记的罕见肿瘤样病变。
