Department of Obstetrics & Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 0SQ, UK.
Department of Anaesthesia, Cambridge University NHS Hospitals Foundation Trust, Cambridge, CB2 0QQ, UK.
BMC Pregnancy Childbirth. 2021 Mar 17;21(1):212. doi: 10.1186/s12884-021-03653-4.
Asymptomatic carriage of COVID-19 in pregnant women has been reported and could lead to outbreaks in maternity units. We sought to ascertain the impact of rapid isothernal nucleic acid based testing for COVID-19 in an unselected cohort of pregnant women attending our maternity unit. We also assessed the correlation between community prevalence and asymptomatic carriage.
Data for the retrospective cohort study were collected from a large UK tertiary maternity unit over a 4-week period using computerised hospital records. Literature searches were performed across multiple repositories. COVID-19 prevalence was extracted from online repositories.
Nasopharyngeal and oropharyngeal swabs were obtained from 457/465 (98%) women during the study period. The median turnaround time for results was 5.3 h (interquartile range (IQR) 2.6-8.9 h), with 92% of the results returned within 24 h. In our cohort, only one woman tested positive, giving a screen positive rate of 0.22% (1/457; 95% CI: 0.04-1.23%). One woman who tested negative developed a fever postnatally following discharge but was lost to follow-up. From our literature review, we did not find any correlation between asymptomatic carriage in pregnant women and the reported regional prevalence of COVID-19.
Testing using the SAMBA-II machine was acceptable to the vast majority of pregnant women requiring admission and had a low turnaround time. Asymptomatic carriage is low, but not correlated to community prevalence rates. Screening pregnant women on admission will remain an important component in order to minimise nosocomial infection.
已有报道称，COVID-19 在孕妇中的无症状携带情况，这可能导致产科病房爆发疫情。我们旨在确定在未选择的孕妇队列中使用等温核酸快速检测 COVID-19 的影响。我们还评估了社区流行率与无症状携带之间的相关性。
回顾性队列研究的数据来自英国一家大型三级产科医院在四周内使用计算机化的医院记录收集。对多个存储库进行了文献检索。从在线存储库中提取 COVID-19 流行率。
在研究期间，从 457/465（98%）名妇女中获得了鼻咽和口咽拭子。结果的中位数周转时间为 5.3 小时（四分位距（IQR）2.6-8.9 小时），92%的结果在 24 小时内返回。在我们的队列中，仅 1 名妇女检测呈阳性，阳性检出率为 0.22%（457 例；95%CI：0.04-1.23%）。一名检测阴性的妇女产后出院后发烧，但失访。从我们的文献综述中，我们没有发现孕妇无症状携带与报告的 COVID-19 区域流行率之间存在任何相关性。
使用 SAMBA-II 机器进行检测，绝大多数需要住院的孕妇都能接受，且周转时间短。无症状携带率低，但与社区流行率无关。入院时对孕妇进行筛查仍将是减少医院感染的重要组成部分。
