Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon, 24252, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan, 18450, Korea.
BMC Oral Health. 2021 Mar 17;21(1):125. doi: 10.1186/s12903-021-01496-1.
Chronic periodontitis is a multifactorial inflammatory disease resulting in patients exhibiting high levels of inflammatory factors causing systemic inflammatory bone destruction that may lead to osteoporosis development. The association between periodontitis and osteoporosis has been documented; however, the findings remain unclear. This study aimed to identify the association between periodontitis and osteoporosis using a cross-sectional study design and Korean Genome and Epidemiology Study (KoGES) health examinee data.
This cross-sectional study used epidemiological data from the KoGES during 2004-2016. Of 125,324 participants (age, 40-79 years), 9969 with periodontitis and 115,332 controls (without periodontitis) were selected. We analyzed the history of osteoporosis and fractures of all participants. All participants were examined according to age, sex, income group, obesity, smoking habits, alcohol consumption, and food intake. To analyze the odds ratio (OR) of periodontitis for those with osteoporosis and fractures, a logistic regression model was used.
The adjusted odds ratio (aOR) of periodontitis for osteoporosis was 2.16 (95% confidence interval [CI], 2.01-2.31; P < 0.001). The aOR of periodontitis for any fracture was 1.54 (95% CI 1.46-1.62; P < 0.001).
Osteoporosis and fractures are associated with periodontitis. Performing regular oral hygiene and examinations of bone mineral density are recommended to prevent aggravation of osteoporosis and periodontitis.
慢性牙周炎是一种多因素炎症性疾病，导致患者表现出高水平的炎症因子，引起系统性炎症性骨破坏，可能导致骨质疏松症的发展。牙周炎和骨质疏松症之间的关联已有记载；然而，结果仍不清楚。本研究旨在使用横断面研究设计和韩国基因组和流行病学研究（KoGES）健康检查数据来确定牙周炎和骨质疏松症之间的关联。
本横断面研究使用了 2004 年至 2016 年 KoGES 的流行病学数据。在 125324 名参与者（年龄 40-79 岁）中，选择了 9969 名患有牙周炎和 115332 名对照（无牙周炎）。我们分析了所有参与者的骨质疏松症和骨折病史。所有参与者均根据年龄、性别、收入群体、肥胖、吸烟习惯、饮酒和饮食进行了检查。为了分析牙周炎对骨质疏松症和骨折患者的比值比（OR），使用了逻辑回归模型。
牙周炎发生骨质疏松症的调整比值比（aOR）为 2.16（95%置信区间[CI]，2.01-2.31；P<0.001）。牙周炎发生任何骨折的 aOR 为 1.54（95%CI 1.46-1.62；P<0.001）。
骨质疏松症和骨折与牙周炎有关。建议定期进行口腔卫生和骨密度检查，以预防骨质疏松症和牙周炎的恶化。
