Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea.
Arch Osteoporos. 2021 Jun 19;16(1):98. doi: 10.1007/s11657-021-00947-0.
We performed a nationwide, population-based cohort study to evaluate the risk of osteoporosis and osteoporotic fracture in patients with breast cancer using the data from Korean Genome and Epidemiology Study (KoGES) and concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, regardless of age.
This study aimed to evaluate the association between breast cancer and the occurrence of osteoporosis and osteoporotic fracture using data from the Korean Genome and Epidemiology Study (KoGES).
Using the national KoGES health examinee (HEXA) data consisting of data from urban resident participants ≥ 40 years old, we extracted data for patients with breast cancer (n = 1080) and for control participants (n = 106,993); we then analyzed the occurrence of osteoporosis and osteoporotic fracture at baseline from 2004 to 2013 and during follow-up from 2012 to 2016. A logistic regression model was used to analyze the odds ratios (ORs) and the 95% confidence intervals (CIs). Subgroup analysis was performed based on age (younger group aged ≤ 51 years old; older group aged ≥ 52 years old).
The ORs (95% CIs) for osteoporosis and osteoporotic fracture were 1.54 (95% CI = 1.28-1.84, P < 0.001) and 1.01 (95% CI = 0.82-1.23, P = 0.949), respectively, in the breast cancer group. In the subgroup analysis based on age, the ORs (95% CIs) for osteoporosis were 2.41 (95% CI = 1.70-3.43, P < 0.001) in the younger group and 1.33 (95% CI = 1.08-1.64, P = 0.007) in the older group of breast cancer patients. The ORs (95% CIs) for osteoporotic fracture were 1.15 (95% CI = 0.81-1.63, P = 0.441) in the younger group and 0.95 (95% CI = 0.74-1.21, P = 0.661) in the older group of breast cancer patients.
We concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture, regardless of age.
本研究旨在使用韩国基因组与流行病学研究（KoGES）的数据评估乳腺癌与骨质疏松症和骨质疏松性骨折发生的相关性。
我们利用包含≥40 岁城市居民参与者数据的全国性 KoGES 健康检查者（HEXA）数据，提取乳腺癌患者（n=1080）和对照组参与者（n=106993）的数据；然后，我们分析了 2004 年至 2013 年基线和 2012 年至 2016 年随访期间骨质疏松症和骨质疏松性骨折的发生情况。使用 logistic 回归模型分析比值比（ORs）和 95%置信区间（CIs）。根据年龄（年龄≤51 岁的年轻组和年龄≥52 岁的老年组）进行亚组分析。
在乳腺癌组中，骨质疏松症和骨质疏松性骨折的 ORs（95%CI）分别为 1.54（95%CI=1.28-1.84，P<0.001）和 1.01（95%CI=0.82-1.23，P=0.949）。在基于年龄的亚组分析中，乳腺癌患者中骨质疏松症的 ORs（95%CI）分别为年轻组的 2.41（95%CI=1.70-3.43，P<0.001）和老年组的 1.33（95%CI=1.08-1.64，P=0.007）。骨质疏松性骨折的 ORs（95%CI）分别为年轻组的 1.15（95%CI=0.81-1.63，P=0.441）和老年组的 0.95（95%CI=0.74-1.21，P=0.661）。
我们得出结论，韩国患有乳腺癌的女性发生骨质疏松症的风险高于健康女性，但无论年龄大小，这种情况并未观察到骨质疏松性骨折。
