Department of Urology, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, 730050, China.
Department of Urology, Gansu Provincial People's Hospital, Lanzhou, 730050, China.
Int J Biochem Cell Biol. 2021 May;134:105968. doi: 10.1016/j.biocel.2021.105968. Epub 2021 Mar 14.
Circular RNA (circRNA) is a member of the non-coding RNA family that is formed by trans-splicing. Because of its unique structure and characteristics, it has extraordinary value for the diagnosis, treatment, and prognosis of diseases, particularly for tumors. Study of the role of circRNAs in the occurrence and development of prostate cancer has made considerable progress, but many areas remain that require further exploration and improvement. This article describes research into sequencing expression profiles, expression regulation, potential value as biomarkers, mechanism in the occurrence and development, therapy resistance, relationship with clinicopathological features, and prognostic value of circRNAs in prostate cancer from the past few years.
环状 RNA（circRNA）是一种通过反式剪接形成的非编码 RNA 家族成员。由于其独特的结构和特性，它在疾病的诊断、治疗和预后方面具有非凡的价值，特别是对于肿瘤。circRNA 在前列腺癌发生发展中的作用的研究已经取得了相当大的进展，但仍有许多领域需要进一步探索和改进。本文从近几年的研究中描述了环状 RNA 在前列腺癌中的测序表达谱、表达调控、作为生物标志物的潜在价值、在发生发展中的作用机制、治疗耐药性、与临床病理特征的关系以及预后价值的研究。
