Department of Urology, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Neoplasma. 2020 Jan;67(1):68-77. doi: 10.4149/neo_2019_190213N116. Epub 2019 Nov 4.
Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the expression of circZMIZ1 was higher in plasma of human prostate cancer than the paired benign prostatic hyperplasia (BPH) patients' plasma. Moreover, in cultured prostate cancer cells, knockdown of circZMIZ1 inhibited cell proliferation and caused cell cycle arrest at G1. Mechanistically, we also showed that circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer. In conclusion, these results revealed that circZMIZ1 might serve as a novel biomarker and a treatment target for prostate cancer treatment.
越来越多的证据证明，环状 RNA（circRNA）作为一种特定的非编码 RNA，在肿瘤发生中发挥着潜在的关键作用，包括前列腺癌。然而，circRNA 在人类前列腺癌中的功能仍知之甚少。在这项研究中，我们证明了 circZMIZ1 在人类前列腺癌患者的血浆中的表达高于配对的良性前列腺增生（BPH）患者的血浆。此外，在培养的前列腺癌细胞中，circZMIZ1 的敲低抑制了细胞增殖，并导致细胞周期停滞在 G1 期。从机制上讲，我们还表明 circZMIZ1 可以增加雄激素受体（AR）和雄激素受体剪接变体 7（AR-V7）的表达，这可能部分促成了前列腺癌的发生和发展。总之，这些结果表明 circZMIZ1 可能作为一种新的生物标志物和治疗靶点用于前列腺癌的治疗。
