The First Clinical Medical College of Lanzhou University, No. 119, Donggang Road West, Chengguan District, Lanzhou, 730000, Gansu Province, China.
Department of Urology, Gansu Provincial Hospital, No. 204, Donggang Road West, Chengguan District, Lanzhou, 730000, Gansu Province, China.
Curr Med Chem. 2024;31(29):4640-4656. doi: 10.2174/0929867330666230531095850.
This study aims to summarize the current literature to demonstrate the importance of circular RNAs (circRNAs) in multiple aspects of prostate cancer (PCa) occurrence, progression, and treatment resistance and explore the potential role in therapeutic strategies aimed at targeting this molecule in PCa.
The relevant literature from PubMed and Medline databases is reviewed in this article.
Non-coding RNA has been proven to play a vital role in regulating tumor progression. Among them, circular RNA plays a more unique role due to its nonlinear structure. Lots of circRNAs were found to be differentially expressed in PCa and regulate cell signaling pathways by regulating particular gene expressions. Recent studies have demonstrated that circRNAs are associated with the chemoresistance of urinary tumors, suggesting that circRNAs might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.
The potential crosstalk of circRNAs modifications in PCa development, therapy, and regulation of tumor metabolism is portrayed in this review. However, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.
本研究旨在总结目前的文献，以证明环状 RNA（circRNA）在前列腺癌（PCa）发生、进展和治疗耐药性的多个方面的重要性，并探讨其在针对 PCa 中该分子的治疗策略中的潜在作用。
本文综述了来自 PubMed 和 Medline 数据库的相关文献。
非编码 RNA 已被证明在调节肿瘤进展中发挥重要作用。其中，环状 RNA 由于其非线性结构而发挥更独特的作用。大量 circRNAs 在 PCa 中差异表达，并通过调节特定基因的表达来调节细胞信号通路。最近的研究表明，circRNAs 与尿肿瘤的化疗耐药性相关，提示 circRNAs 可能是一种新的治疗靶点，以及治疗反应和预后评估的标志物。
本综述描绘了 circRNAs 修饰在 PCa 发展、治疗和肿瘤代谢调控中的潜在串扰。然而，针对该靶向策略的更多临床前和临床试验对于治疗尿肿瘤是必要的。
