Sato I, Nishimura T, Kakimoto N, Suzuki H, Tanaka N
Institute of Applied Microbiology, University of Tokyo, Japan.
J Biol Response Mod. 1988 Feb;7(1):1-5.
The pulmonary metastasis of Lewis lung carcinoma was strongly blocked by daily intraperitoneal (i.p.) treatment with 0.5 mg of PCAGeS/kg/day for 7 days after tumor implantation. The metastasis-preventive activity of PCAGeS was markedly reduced when mice were treated with carrageenan, a macrophage blocker. On the other hand, treatment with antiasialo GM1 antiserum did not significantly affect the percentage of inhibition of metastasis by the compound. These results suggest that macrophages rather than natural killer (NK) cells play an important role in the suppression of metastasis by PCAGeS. PCAGeS induced tumoristatic and tumoricidal activities in the peritoneal macrophages of mice by oral administration. The activity of NK cells was also augmented by i.p. treatment with the compound. These results suggest that PCAGeS is a useful substance for preventing pulmonary metastasis.
在肿瘤接种后，每天腹腔注射0.5毫克PCAGeS/千克/天，持续7天，可强烈抑制Lewis肺癌的肺转移。当用巨噬细胞阻断剂角叉菜胶处理小鼠时，PCAGeS的转移预防活性显著降低。另一方面，用抗唾液酸GM1抗血清处理对该化合物抑制转移的百分比没有显著影响。这些结果表明，巨噬细胞而非自然杀伤（NK）细胞在PCAGeS抑制转移中起重要作用。通过口服给药，PCAGeS可诱导小鼠腹腔巨噬细胞产生肿瘤抑制和杀肿瘤活性。通过腹腔注射该化合物也可增强NK细胞的活性。这些结果表明，PCAGeS是一种预防肺转移的有用物质。
