Sato I, Yuan B D, Nishimura T, Tanaka N
J Biol Response Mod. 1985 Apr;4(2):159-68.
The effects of two novel organic germanium compounds, 1-phenyl-2-carbamoylethylgermanium sesquisulfide (PCAGeS) and 1-phenyl-2-carbamoylethylgermanium sequioxide (PCAGeO), on transplantable murine tumors and immune responses were studied. Both drugs showed low toxicity for mice. In culture, neither substance displayed significant cytotoxicity against murine tumor cells L1210 leukemia, L5178Y lymphoma, or IMC carcinoma. Growth of subcutaneously transplanted IMC carcinoma or Meth-A fibrosarcoma was markedly reduced by oral administration of PCAGeS. PCAGeO exhibited a similar but smaller effect on the tumor growth. Pulmonary metastasis of Lewis lung carcinoma was inhibited by oral or intraperitoneal treatment with PCAGeS. The activity of cyclophosphamide or Adriamycin against L1210 leukemia was significantly potentiated by oral administration of PCAGeS. PCAGeS enhanced the delayed-type hypersensitivity response to sheep red blood cells (SRBC) of mice or restored the response suppressed by ascitic IMC carcinoma, but did not significantly affect the formation of antibody to SRBC. PCAGeO similarly stimulated the DTH reaction. Phagocytic activity of peritoneal macrophages was enhanced by oral treatment of mice with PCAGeS. The results suggest that PCAGeS and PCAGeO display tumor-inhibitory activity by modification of the immune mechanism.
研究了两种新型有机锗化合物，即1-苯基-2-氨甲酰乙基锗倍半硫化物（PCAGeS）和1-苯基-2-氨甲酰乙基锗二氧化物（PCAGeO）对可移植性小鼠肿瘤及免疫反应的影响。两种药物对小鼠均显示出低毒性。在培养实验中，两种物质对小鼠肿瘤细胞L1210白血病细胞、L5178Y淋巴瘤细胞或IMC癌细胞均未表现出显著的细胞毒性。口服PCAGeS可显著抑制皮下移植的IMC癌或Meth-A纤维肉瘤的生长。PCAGeO对肿瘤生长也有类似但较弱的作用。口服或腹腔注射PCAGeS可抑制Lewis肺癌的肺转移。口服PCAGeS可显著增强环磷酰胺或阿霉素对L1210白血病的活性。PCAGeS增强了小鼠对绵羊红细胞（SRBC）的迟发型超敏反应，或恢复了被IMC癌腹水抑制的反应，但对SRBC抗体的形成没有显著影响。PCAGeO同样刺激了迟发型超敏反应。口服PCAGeS可增强小鼠腹腔巨噬细胞的吞噬活性。结果表明，PCAGeS和PCAGeO通过调节免疫机制发挥肿瘤抑制活性。
