Ramdhan Doni Hikmat, Kurniasari Fitri, Tejamaya Mila, Fitri Aidila, Indriani Aisyah, Kusumawardhani Adinda, Santoso Muhayatun
Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Indonesia.
Center of Nuclear Technology for Materials and Radiometry, BATAN Bandung, Indonesia.
Saf Health Work. 2021 Mar;12(1):114-118. doi: 10.1016/j.shaw.2020.08.005. Epub 2020 Aug 29.
Exposure to particulate matter (PM) emitted from vehicle exhaust might disrupt systemic function and elevate the risk of cardiovascular disease. In this study, we examined the changes of cardiometabolic biomarkers among vehicle inspectors exposed daily to PM0.25 and components.
This cross-sectional study was conducted at two vehicle inspection centers, Pulogadung and Ujung Menteng, located in East Jakarta, Indonesia. The exposed respondents were 43 workers from vehicle inspection centers, and the unexposed group consisted of 22 staff officers working in the same locations. Vehicle exhaust particulate matter was measured for eight hours using a Leland Legacy personal pump attached to a Sioutas Cascade Impactor. The used filters were 25 and 37-mm quartz filters. The particulate matter concentration was analyzed using a gravimetric method, whereas trace elements were analyzed using energy dispersive X-ray fluorescence. An EEL Smoke Stain Reflectometer analyzed black carbon.
The personal exposure concentrations of PM0.25 were 10.4-fold higher than those in unexposed groups. Calcium and sulfur were the major components in the obtained dust, and their levels were 3.3- and 7.2-fold higher, respectively, in the exposed group. Based on an independent-samples -test, high-density lipoprotein, triglyceride, HbA1c, total immunoglobulin E, high-sensitivity C-reactive protein, tumor necrosis factor-alpha, and nitric oxide levels were significantly different between the groups.
In summary, it was suggested that PM0.25 exposure from vehicle exhaust might affect cardiometabolic biomarkers change.
暴露于汽车尾气排放的颗粒物（PM）可能会扰乱全身功能并增加心血管疾病风险。在本研究中，我们调查了每日暴露于PM2.5及其成分的车辆检查员心脏代谢生物标志物的变化。
这项横断面研究在位于印度尼西亚雅加达东部的两个车辆检查中心进行，分别是Pulogadung和Ujung Menteng。暴露组为43名来自车辆检查中心的工人，未暴露组由在同一地点工作的22名工作人员组成。使用连接到Sioutas级联撞击器的Leland Legacy个人泵对汽车尾气颗粒物进行8小时测量。使用的过滤器是25毫米和37毫米的石英过滤器。采用重量法分析颗粒物浓度，采用能量色散X射线荧光法分析微量元素。使用EEL烟斑反射仪分析黑碳。
PM2.5的个人暴露浓度比未暴露组高10.4倍。钙和硫是所获灰尘中的主要成分，其在暴露组中的含量分别高出3.3倍和7.2倍。基于独立样本检验，两组之间的高密度脂蛋白、甘油三酯、糖化血红蛋白、总免疫球蛋白E、高敏C反应蛋白、肿瘤坏死因子-α和一氧化氮水平存在显著差异。
总之，提示汽车尾气中的PM2.5暴露可能会影响心脏代谢生物标志物的变化。
