Du Yixing, Xu Xiaohan, Chu Ming, Guo Yan, Wang Junhong
1 Department of Gerontology, 2 Department of Neurology, 3 Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
J Thorac Dis. 2016 Jan;8(1):E8-E19. doi: 10.3978/j.issn.2072-1439.2015.11.37.
Air pollution is now becoming an independent risk factor for cardiovascular morbidity and mortality. Numerous epidemiological, biomedical and clinical studies indicate that ambient particulate matter (PM) in air pollution is strongly associated with increased cardiovascular disease such as myocardial infarction (MI), cardiac arrhythmias, ischemic stroke, vascular dysfunction, hypertension and atherosclerosis. The molecular mechanisms for PM-caused cardiovascular disease include directly toxicity to cardiovascular system or indirectly injury by inducing systemic inflammation and oxidative stress in peripheral circulation. Here, we review the linking between PM exposure and the occurrence of cardiovascular disease and discussed the possible underlying mechanisms for the observed PM induced increases in cardiovascular morbidity and mortality.
空气污染正日益成为心血管疾病发病和死亡的独立危险因素。大量流行病学、生物医学和临床研究表明，空气污染中的环境颗粒物（PM）与心血管疾病风险增加密切相关，如心肌梗死（MI）、心律失常、缺血性中风、血管功能障碍、高血压和动脉粥样硬化。PM导致心血管疾病的分子机制包括对心血管系统的直接毒性作用，或通过诱导外周循环中的全身炎症和氧化应激造成间接损伤。在此，我们综述了PM暴露与心血管疾病发生之间的联系，并讨论了所观察到的PM导致心血管疾病发病率和死亡率上升的潜在机制。
