Farrell C L, Megyesi J, Del Maestro R F
Department of Clinical Neurological Sciences, University of Western Ontario, Victoria Hospital, London, Canada.
J Neurosurg. 1988 Jun;68(6):925-30. doi: 10.3171/jns.1988.68.6.0925.
The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or the implantation technique, thereby interfering with the ability of the tumors to grow.
在大鼠胶质瘤模型中评估了长期低剂量和高剂量布洛芬对肿瘤生长和通透性的影响。在植入C6星形细胞瘤球体前24小时，用布洛芬（24毫克/千克/天或96毫克/千克/天）对大鼠进行治疗，然后在植入后持续治疗13天。采用伊文思蓝染料技术测量肿瘤的湿重和干重以及蛋白外渗情况。根据肿瘤干重评估时，治疗似乎并未降低蛋白外渗。与未治疗大鼠的肿瘤湿重相比，高剂量和低剂量布洛芬治疗的大鼠肿瘤湿重显著降低。与未治疗对照动物的肿瘤相比，高剂量布洛芬治疗显著降低了肿瘤的干重。据推测，所采用的布洛芬治疗方案抑制了由C6肿瘤细胞生长和/或植入技术诱导的前列腺素相关血管生成，从而干扰了肿瘤的生长能力。
