Aas A T, Tønnessen T I, Brun A, Salford L G
Department of Neurosurgery, Lund University Hospital, Sweden.
J Neurooncol. 1995;24(2):171-80. doi: 10.1007/BF01078487.
The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied. The in vitro studies reveal that aspirin and salicylic acid strongly inhibit growth of rat glioma (RG 2) cells in concentrations used in medicine for treatment of rheumatic diseases. On the other hand, indomethacin and piroxicam had no effect, indicating that the inhibitory effect on tumor growth is not due to the inhibition of prostaglandin synthesis. The synthesis of ATP was markedly reduced (34% of control) in the presence of drugs, whereas protein synthesis measured as 3H-leucine incorporation was slightly more inhibited (73% of control) than cell growth. Aspirin administered to Fischer 344 rats inhibited growth of RG 2 cells inoculated into the caudate nucleus in vivo, both when administered the day before inoculation of tumor cells and when tumors had formed, i.e. 5 days post inoculation.
研究了非甾体抗炎药（NSAIDs）、乙酰水杨酸（俗称阿司匹林）、水杨酸、吡罗昔康和吲哚美辛对大鼠胶质瘤细胞（RG 2）体外生长的影响以及阿司匹林对其体内生长的影响。体外研究表明，阿司匹林和水杨酸在用于治疗风湿性疾病的药物浓度下能强烈抑制大鼠胶质瘤（RG 2）细胞的生长。另一方面，吲哚美辛和吡罗昔康没有效果，这表明对肿瘤生长的抑制作用并非由于前列腺素合成的抑制。在药物存在的情况下，ATP的合成显著减少（为对照的34%），而以3H-亮氨酸掺入量衡量的蛋白质合成比细胞生长受到的抑制略多（为对照的73%）。给Fischer 344大鼠服用阿司匹林，无论是在接种肿瘤细胞前一天给药，还是在肿瘤形成后（即接种后5天）给药，都能抑制接种到尾状核中的RG 2细胞的生长。
