Rao V K, Feldman P D, Dibbell D G
Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine, Madison.
J Neurosurg. 1988 Jun;68(6):967-9. doi: 10.3171/jns.1988.68.6.0967.
Extravasation of intravenous phenytoin can result in serious soft-tissue complications. Three patients are presented, one of whom lost a hand. Assessment of circulation and early decompression fasciotomies may be necessary in such cases. Caution is recommended in the intravenous administration of phenytoin. Infusions at rates of less than 50 mg/min and education of nursing staff about this potential complication will decrease its incidence.