Diaz-Uriarte Ramon
Department of Biochemistry, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas "Alberto Sols" (UAM-CSIC), Madrid, Spain.
Methods Mol Biol. 2021;2212:121-154. doi: 10.1007/978-1-0716-0947-7_9.
I show how to use OncoSimulR, software for forward-time genetic simulations, to simulate evolution of asexual populations in the presence of epistatic interactions. This chapter emphasizes the specification of fitness and epistasis, both directly (i.e., specifying the effects of individual mutations and their epistatic interactions) and indirectly (using models for random fitness landscapes).
我展示了如何使用OncoSimulR（一种用于正向时间遗传模拟的软件）来模拟存在上位性相互作用时无性种群的进化。本章重点介绍了适应度和上位性的指定，包括直接指定（即指定单个突变的效应及其上位性相互作用）和间接指定（使用随机适应度景观模型）。
