BOB.1/OBF.1 缺陷小鼠派尔集合淋巴结发育受损。

Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice.

机构信息

Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.

Institute of Physiological Chemistry, Ulm University, Ulm, Germany.

出版信息

Eur J Immunol. 2021 Jul;51(7):1860-1863. doi: 10.1002/eji.202048578. Epub 2021 Mar 26.

DOI:10.1002/eji.202048578

PMID:33733501

Abstract

BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LT and LT cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development.

摘要

BOB.1/OBF.1 的表达调控直接和间接靶基因的转录。我们提出，BOB.1/OBF.1 影响胚胎派伊尔氏斑器官发生过程中的 LT 和 LT 细胞的 CXCL13-CXCR5 信号，以及次级淋巴器官发育过程中淋巴细胞归巢时的 B 细胞和滤泡树突状细胞。