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沙罗拉纳的设计与合成，一种新型的每月口服一次的异恶唑啉类药物，用于防治犬只跳蚤和蜱虫。

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs.

作者信息

Curtis Michael P, Vaillancourt Valerie, Goodwin Richard M, Chubb Nathan A L, Howson William, McTier Tom L, Pullins Aleah, Zinser Erich W, Meeus Patrick F M, Woods Debra J, Hedges Laura, Stuk Tim, Price Jeffrey E, Koch Jason D, Menon Sanjay R

机构信息

Department of Medicinal Chemistry, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.

Department of Parasitology, Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.

出版信息

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1831-5. doi: 10.1016/j.bmcl.2016.02.027. Epub 2016 Feb 12.

DOI:10.1016/j.bmcl.2016.02.027
PMID:26920802
Abstract

Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.

摘要

在过去十年中，异恶唑啉结构已成为作物保护和动物健康领域公司在寻找新型杀虫剂和杀体外寄生虫剂时的重点关注对象。在此，我们报告沙罗拉纳的发现，这是一种专为动物健康使用而优化的专利异恶唑啉，用于每月一次口服治疗犬类跳蚤和蜱虫感染。

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