含塞拉菌素和沙罗拉纳的滴剂组合产品（强力卫士 Plus）治疗猫自然感染的疗效。
Efficacy of a spot-on combination product containing selamectin and sarolaner (Stronghold Plus) in the treatment of naturally occurring infestations in cats.
作者信息
Borowski Stasia, Berlamont Helena, Geurden Thomas, D'Hanis Lina, Rapti Dhimiter, Cvejić Dejan, Suckstorff Oliver, Simović Nikola, King Vickie L
机构信息
Zoetis, Veterinary Medicine Research and Development, Zaventem, Belgium.
Klinika Xhimi, Bulevardi Bajram Curri, Tirana, Albania.
出版信息
Front Vet Sci. 2025 Aug 21;12:1652148. doi: 10.3389/fvets.2025.1652148. eCollection 2025.
Notoedric mange (also known as feline scabies) is a highly contagious and intensely pruritic dermatologic condition of cats caused by infestation with mites. Previous publications provide evidence that topical selamectin, and more recently, topical selamectin + sarolaner is efficacious in the treatment of notoedric mange in cats. The study reported here was conducted to confirm the efficacy of a topically applied combination of selamectin and sarolaner (Stronghold Plus) in the treatment of notoedric mange in cats naturally infested with Client-owned cats with clinical signs of notoedric mange and positive for live mites were enrolled and allocated randomly to treatment with either placebo ( = 10) or Stronghold Plus ( = 10). Treatment was administered on Days 0 and 30, and skin scrapings to detect live mites and assessment of the clinical signs of notoedric mange were conducted on Days 0, 30, and 60. The primary efficacy evaluation was based on the percent reduction in live mite counts in Stronghold Plus-treated cats compared to placebo-treated cats on Day 30. The parasitological cure (i.e., no live mites found) on Days 30 and 60 was also calculated for both treatment groups, as well as the improvement in clinical signs of notoedric mange. A single topical administration of Stronghold Plus provided a significant ( 0.0001) and 100% reduction in live mites relative to placebo within 30 days. All placebo-treated cats harbored mites on Days 30 and 60, while none of the Stronghold Plus-treated cats had any live mites. Parasitological cure on Days 30 and 60 was thus 100% and significantly different than placebo ( 0.0001). Clinical signs of notoedric mange improved in the Stronghold Plus-treated cats by Day 30, and no signs of notoedric mange were observed by Day 60. This study confirms that Stronghold Plus is highly effective in the treatment of notoedric mange in cats naturally infested with
耳螨疥癣（也称为猫疥螨病）是一种由螨虫感染引起的猫的高度传染性且剧痒的皮肤病。先前的出版物提供了证据表明，局部使用塞拉菌素，以及最近的局部使用塞拉菌素+沙罗拉纳对治疗猫的耳螨疥癣有效。此处报告的研究旨在确认局部应用塞拉菌素和沙罗拉纳的组合（硕腾加）对自然感染耳螨疥癣的猫的治疗效果。将有耳螨疥癣临床症状且活螨检测呈阳性的客户拥有的猫纳入研究，并随机分配接受安慰剂治疗（n = 10）或硕腾加治疗（n = 10）。在第0天和第30天进行治疗，并在第0天、第30天和第60天进行皮肤刮片以检测活螨并评估耳螨疥癣的临床症状。主要疗效评估基于与安慰剂治疗的猫相比，在第30天时硕腾加治疗的猫活螨数量减少的百分比。还计算了两个治疗组在第30天和第60天的寄生虫学治愈情况（即未发现活螨），以及耳螨疥癣临床症状的改善情况。单次局部应用硕腾加在30天内相对于安慰剂使活螨数量显著减少（P < 0.0001）且减少了100%。所有接受安慰剂治疗的猫在第30天和第60天都有螨虫，而接受硕腾加治疗的猫没有任何活螨。因此，第30天和第60天的寄生虫学治愈率为100%，且与安慰剂有显著差异（P < 0.0001）。到第30天时，接受硕腾加治疗的猫的耳螨疥癣临床症状有所改善，到第60天时未观察到耳螨疥癣的症状。本研究证实，硕腾加对自然感染耳螨疥癣的猫的治疗非常有效。
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