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硝基呋喃妥因相关性急性化脓性间质性肾炎。

Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis.

机构信息

SUNY Upstate Medical University, Syracuse, NY, USA.

出版信息

J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211001659. doi: 10.1177/23247096211001659.

DOI:10.1177/23247096211001659
PMID:33733898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7983233/
Abstract

We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an anticipated urological procedure. Renal biopsy demonstrated acute granulomatous interstitial nephritis. The renal function significantly improved following discontinuation of nitrofurantoin and corticosteroid administration. We highlight a rare association of nitrofurantoin with acute granulomatous interstitial nephritis through this case report.

摘要

我们报告了一例 71 岁女性的病例,她在因新发视觉幻觉进行常规检查时意外发现非少尿性急性肾损伤。进一步的病史显示,她曾在 3 个月前因预期的泌尿科手术而意外使用了呋喃妥因。肾活检显示急性肉芽肿性间质性肾炎。停用呋喃妥因和给予皮质类固醇后,肾功能显著改善。通过本病例报告,我们强调了呋喃妥因与急性肉芽肿性间质性肾炎之间的罕见关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/c5fb72b561ec/10.1177_23247096211001659-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/885426c89ad0/10.1177_23247096211001659-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/d14ad1ce890f/10.1177_23247096211001659-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/c5fb72b561ec/10.1177_23247096211001659-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/885426c89ad0/10.1177_23247096211001659-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/d14ad1ce890f/10.1177_23247096211001659-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72d/7983233/c5fb72b561ec/10.1177_23247096211001659-fig3.jpg

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本文引用的文献

1
Granulomatous interstitial nephritis.肉芽肿性间质性肾炎
Clin Kidney J. 2015 Oct;8(5):516-23. doi: 10.1093/ckj/sfv053. Epub 2015 Jul 5.
2
Biopsy-proven acute interstitial nephritis, 1993-2011: a case series.经活检证实的急性间质性肾炎,1993-2011 年:病例系列。
Am J Kidney Dis. 2014 Oct;64(4):558-66. doi: 10.1053/j.ajkd.2014.04.027. Epub 2014 Jun 11.
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Acute interstitial nephritis.急性间质性肾炎。
Kidney Int. 2010 Jun;77(11):956-61. doi: 10.1038/ki.2010.89. Epub 2010 Mar 24.
4
Acute renal failure from nitrofurantoin-induced acute granulomatous interstitial nephritis.由呋喃妥因引起的急性间质性肾炎导致急性肾衰竭。
QJM. 2010 Jan;103(1):49-52. doi: 10.1093/qjmed/hcp146. Epub 2009 Oct 14.
5
Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis.早期使用类固醇治疗可改善药物性急性间质性肾炎患者的肾功能恢复情况。
Kidney Int. 2008 Apr;73(8):940-6. doi: 10.1038/sj.ki.5002776. Epub 2008 Jan 9.
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Granulomatous interstitial nephritis.肉芽肿性间质性肾炎
Clin J Am Soc Nephrol. 2007 Mar;2(2):222-30. doi: 10.2215/CJN.01790506. Epub 2007 Jan 17.
7
Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases.老年人急性肾功能不全的病因及预后:259例肾活检研究
Am J Kidney Dis. 2000 Mar;35(3):433-47. doi: 10.1016/s0272-6386(00)70196-x.
8
Acute granulomatous interstitial nephritis due to nitrofurantoin.呋喃妥因所致急性肉芽肿性间质性肾炎。
Nephrol Dial Transplant. 1994;9(6):713-5. doi: 10.1093/ndt/9.6.713.