Guangxi Key Laboratory of New Energy and Building Energy Saving, Guilin University of Technology, Guilin, China.
College of Civil and Architecture Engineering, Guilin University of Technology, Guilin, China.
Nat Prod Res. 2022 Aug;36(15):3924-3930. doi: 10.1080/14786419.2021.1900177. Epub 2021 Mar 18.
A new highly oxygenated -atisane diterpenoid, namely excagallonoid A (), together with five known analogues (-) were isolated from the leaves and twigs of . Their structures were elucidated on the basis of extensive spectroscopic analyses (HRESIMS, UV, IR, 1 D and 2 D NMR), and the absolute configurations of and were determined by single-crystal X-ray diffraction. Compound represents the first example of an -atisane diterpenoid featuring a vicinal 2,3-diol moiety. Compounds and exhibited weak cytotoxicities against RKO colon cancer cells with IC values of 28.7 ± 1.98 and 32.6 ± 2.81 µM, respectively.
从叶片和嫩枝中分离得到一种新的高度氧化的 -atisane 二萜类化合物，即 excagallonoid A ()，此外还分离得到了 5 种已知类似物（-）。基于广泛的光谱分析（HRESIMS、UV、IR、1D 和 2D NMR）确定了它们的结构，并通过单晶 X 射线衍射确定了和的绝对构型。化合物代表了具有邻位 2,3-二醇部分的 -atisane 二萜类化合物的第一个实例。化合物和对 RKO 结肠癌细胞表现出较弱的细胞毒性，IC 值分别为 28.7 ± 1.98 和 32.6 ± 2.81 μM。
