Unité Médico-Judiciaire, Assistance Publique des Hôpitaux de Paris - Hôtel Dieu, Paris, France.
UFR de médecine, Université de Paris, Paris, France.
Clin Toxicol (Phila). 2021 Nov;59(11):1027-1030. doi: 10.1080/15563650.2021.1892719. Epub 2021 Mar 18.
Misuse/abuse of pregabalin is increasing worldwide. French Poison Control Centers (PCCs) recently received several unusual calls regarding the recreational use of pregabalin in adolescents. This study aims to describe this new and specific population of pregabalin misusers.
We extracted all cases of pregabalin intentional exposures reported to the French National Database of Poisonings (FNDP) from 2004 to 2020. We compared the proportion of recreational exposure to pregabalin between adolescents (10-17 years) and adults (>18 years). We reviewed all cases of pregabalin recreational exposures in adolescent in order to describe the characteristics of this population.
During the study period, 382 cases of acute intentional exposure to pregabalin were reported in adolescents and 1188 in adults, 94/382 (24.6%) and 43/1188 (3.6%) were pregabalin recreational use, respectively ( < .0001). Almost all cases of pregabalin recreational use in adolescent were reported from 2018 (86/94; 91%). Most of those adolescent patients were males (male/female ratio - 5.3:1) and the median age was 15 years (range: 11-17.8). They were homeless or living in migrant shelters in most of the cases (73/90, 81%). Two-third of these exposures (62/94; 66%) involved other toxicant(s) than pregabalin. Most of the patients remains asymptomatic (10/94; 11%), or developed minor to moderate neurological symptoms (76/94; 81%). Eight developed severe symptoms (8/94; 8%) including coma (5/8) or generalized seizures (2/8). Five patients (5/8) required oro-tracheal intubation. No fatality was reported.
We observed a sharp increase in pregabalin recreational use in adolescents in France. It should lead to prevention campaigns, targeted at the population at risk described in this study.
pregabalin 的误用/滥用在全球范围内呈上升趋势。法国中毒控制中心（PCC）最近接到了几通关于青少年娱乐性使用 pregabalin 的不寻常电话。本研究旨在描述这一新的、特定的 pregabalin 滥用人群。
我们从 2004 年至 2020 年从法国国家中毒数据库（FNDP）中提取了所有报告的 pregabalin 故意暴露病例。我们比较了青少年（10-17 岁）和成年人（>18 岁）中 pregabalin 娱乐性暴露的比例。我们回顾了所有青少年娱乐性暴露的 pregabalin 病例，以描述该人群的特征。
在研究期间，报告了 382 例青少年急性故意接触 pregabalin 和 1188 例成人急性故意接触 pregabalin，其中 94/382（24.6%）和 43/1188（3.6%）为 pregabalin 娱乐性使用，差异有统计学意义（<.0001）。青少年中几乎所有的 pregabalin 娱乐性使用病例均来自 2018 年（86/94；91%）。这些青少年患者大多数为男性（男女比例为 5.3:1），中位年龄为 15 岁（范围：11-17.8 岁）。大多数情况下，他们无家可归或居住在移民收容所（73/90，81%）。这些暴露中有三分之二（62/94；66%）涉及 pregabalin 以外的其他毒物。大多数患者无症状（10/94；11%）或出现轻度至中度神经症状（76/94；81%）。8 例出现严重症状（8/94；8%），包括昏迷（5/8）或全身发作（2/8）。5 例患者（5/8）需要气管插管。无死亡报告。
我们观察到法国青少年娱乐性使用 pregabalin 的急剧增加。这应该导致预防运动，针对本研究中描述的高危人群。
