Centre antipoison de Paris - Fédération de toxicologie (FeTox), hôpital Fernand-Widal, AP-HP, 75010 Paris, France; Inserm, UMRS-1144, Faculté de pharmacie, 75006 Paris, France; Unité Médico-judiciaire, Hôtel-Dieu, AP-HP, 75001 Paris, France; UFR de médecine, université de Paris, 75010 Paris, France.
Centre antipoison de Paris - Fédération de toxicologie (FeTox), hôpital Fernand-Widal, AP-HP, 75010 Paris, France; Service de médecine interne, hôpital d'instruction des armées Bégin, 94160 Saint-Mandé, France.
Rev Med Interne. 2022 Jul;43(7):402-405. doi: 10.1016/j.revmed.2022.06.004. Epub 2022 Jun 15.
Recreational use of nitrous oxide (NO) is increasing in Western countries, including France. During the COVID-19 pandemic, some authors warned that recreational NO use could increase further as the supply of illicit drugs was impacted by various containment measures.
We retrospectively analyzed NO exposures reported to the Paris Poison Control Center (France) from 2010/01/01 to 2021/04/15. The Poison Severity Score was used to grade severity.
During the study period, 93 cases of NO recreational exposures were reported (male/female ratio: 1.1; median age: 20.9 years range: [14.8-49.0]). The first case was reported in 2012, 84/93 (90%) and 65/93 (70%) were reported since 2019 and March 17 2020 (first lockdown in France) respectively. Most of the patients were symptomatic (88/93; 95%) and developed neurological symptoms (78/93; 84%). Among the fourteen patients who developed moderate to severe symptoms, eleven were reported after March 2020.
Despite a marked increase in recreational NO exposures during the COVID-19 pandemic, the exact impact of COVID-19 on this increase remains to be determined as it was observed from 2019.
在西方国家，包括法国在内，娱乐性吸食一氧化二氮（NO）的现象正在增加。在 COVID-19 大流行期间，一些作者警告说，随着各种遏制措施对非法毒品供应的影响，娱乐性 NO 使用可能会进一步增加。
我们回顾性分析了 2010 年 1 月 1 日至 2021 年 4 月 15 日期间向巴黎中毒控制中心（法国）报告的一氧化二氮娱乐性暴露病例。使用中毒严重程度评分来分级严重程度。
在研究期间，共报告了 93 例一氧化二氮娱乐性暴露病例（男女比例：1.1；中位数年龄：20.9 岁[14.8-49.0]）。首例报告于 2012 年，84/93（90%）和 65/93（70%）分别于 2019 年和 2020 年 3 月 17 日（法国第一次封锁）报告。大多数患者有症状（88/93；95%），并出现神经系统症状（78/93；84%）。在 14 名出现中重度症状的患者中，有 11 名是在 2020 年 3 月之后报告的。
尽管 COVID-19 大流行期间娱乐性一氧化二氮暴露显著增加，但 COVID-19 对这种增加的确切影响仍有待确定，因为这是从 2019 年开始观察到的。
