Departments of Medicine; and.
Behavioral and Social Sciences, Brown University, Providence, RI.
J Acquir Immune Defic Syndr. 2021 Jul 1;87(3):937-943. doi: 10.1097/QAI.0000000000002671.
The aim of this study was to evaluate the efficacy of a novel, brief 2-session behavioral intervention to promote HIV pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) who are behaviorally at risk for HIV.
A pilot randomized controlled trial was conducted at a sexually transmitted infection (STI) clinic to compare a brief motivational interviewing intervention with passive referral only for PrEP uptake.
MSM who scored as "high risk" on the HIV Incidence Risk index for MSM was offered a brief (15-20 minutes) motivational interviewing-based intervention at the time of STI testing to address barriers to PrEP uptake, including low risk perception, stigma, side effects, and cost. The initial session was followed by a brief, telephone booster session that lasted <10 minutes. The primary outcome was attending a clinical PrEP appointment and accepting a prescription for PrEP.
Participants were recruited from an urban STI clinic in the United States. A total of 86 MSM who were behaviorally at risk for HIV were enrolled in the study (N = 43 intervention; N = 43 treatment-as-usual, "TAU"). Participants randomized to the intervention were significantly more likely to attend a clinical appointment and accept a prescription for PrEP, compared with treatment-as-usual (52.3% versus 27.9%, respectively; odds ratio = 3.6; 95% confidence interval: 1.5 to 8.9; P = 0.005).
A brief behavioral intervention focused on the initial steps in the PrEP care cascade demonstrated preliminary efficacy in promoting uptake among MSM who are behaviorally at risk for HIV.
本研究旨在评估一种新的、简短的两阶段行为干预措施在促进有性行为感染 HIV 风险的男男性行为者（MSM）中采用 HIV 暴露前预防（PrEP）方面的疗效。
在性传播感染（STI）诊所进行了一项试点随机对照试验，比较了简短的动机访谈干预与仅被动转介 PrEP 采用率。
在 STI 检测时，对 HIV 发生率风险指数（MSM）中得分“高风险”的 MSM 提供简短（15-20 分钟）基于动机访谈的干预，以解决 PrEP 采用的障碍，包括低风险认知、耻辱感、副作用和费用。初始阶段后，进行了简短的电话强化阶段，持续时间<10 分钟。主要结果是参加临床 PrEP 预约并接受 PrEP 处方。
参与者从美国的一家城市 STI 诊所招募。共有 86 名有性行为感染 HIV 风险的 MSM 参加了这项研究（N=43 名干预组；N=43 名常规治疗组，即 TAU）。与常规治疗相比，随机分配到干预组的参与者更有可能参加临床预约并接受 PrEP 处方（分别为 52.3%和 27.9%；优势比=3.6；95%置信区间：1.5 至 8.9；P=0.005）。
专注于 PrEP 护理级联初始步骤的简短行为干预在促进有性行为感染 HIV 风险的 MSM 中采用方面初步显示出疗效。
