Israeli Ministry of Health, Jerusalem, Israel.
Faculty of Medicine, Ariel University, Israel.
Isr Med Assoc J. 2021 Mar;23(3):186-190.
Hospitalization of ulcerative colitis patients is needed in severe exacerbation of the disease or for managing complications. In this systematic review and meta-analysis the prevalence of hospitalization in ulcerative colitis and possible predictive factors are discussed. A systematic literature search of English language publications that were published before 31 December 2019 was conducted. Retrospective cohort studies describing hospitalizations of UC patients were included. Meta-analysis was performed by using comprehensive meta-analysis software. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated for the number of patients hospitalized. Seven studies and 15 datasets were found that fulfilled the inclusion criteria. In total, the studies included 2067 patients from six countries. The event rates for the number of patients hospitalized in a follow-up duration of 42,320 patient-years and for the number of patients underwent operation in a follow-up of 24,650 patient-years were 0.065 (95%CI 0.063-0.068) and 0.019 (95%CI 0.017-0.021), respectively. More studies during the era of biologics need to be performed to identify the factors predictive of hospitalization and surgery with UC. Prevention of inflammation and UC complications may prevent hospitalization and the need for surgical treatment.
在溃疡性结肠炎（UC）疾病严重恶化或出现并发症时，患者需要住院治疗。本系统综述和荟萃分析讨论了 UC 患者住院的发生率和可能的预测因素。我们对 2019 年 12 月 31 日前发表的英文文献进行了系统检索。纳入描述 UC 患者住院情况的回顾性队列研究。采用综合荟萃分析软件进行荟萃分析。计算了住院患者人数的汇总优势比（OR）和 95%置信区间（95%CI）。共发现 7 项研究和 15 个数据集符合纳入标准。这些研究共纳入来自 6 个国家的 2067 例患者。在 42320 名患者年的随访期间，有患者住院的事件发生率为 0.065（95%CI 0.063-0.068），在 24650 名患者年的随访期间，有患者接受手术的事件发生率为 0.019（95%CI 0.017-0.021）。需要开展更多生物制剂时代的研究，以确定 UC 患者住院和手术的预测因素。预防炎症和 UC 并发症可能有助于预防住院和手术治疗。
