Socher S H, Martinez D, Craig J B, Kuhn J G, Oliff A
Department of Cancer Research, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
J Natl Cancer Inst. 1988 Jun 15;80(8):595-8. doi: 10.1093/jnci/80.8.595.
Tumor necrosis factor (TNF) has been implicated in the pathogenesis of cachexia in neoplastic and infectious diseases. To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%-40% of premorbid weight. The weight loss experienced by these patients was not attributable to anticancer therapy, gastrointestinal disorders, or other medical problems. TNF was measured using a quantitative sandwich enzyme-linked immunosorbent assay that is sensitive to human TNF in serum at concentrations greater than or equal to 40 pg/mL. No TNF was detected in serum samples from the 19 patients studied.
肿瘤坏死因子（TNF）与肿瘤性疾病和感染性疾病恶病质的发病机制有关。为评估肿瘤坏死因子与癌症患者体重减轻之间的关系，我们检测了19例体重较病前减轻8%-40%的患者血清中的TNF水平。这些患者体重减轻并非抗癌治疗、胃肠道疾病或其他医学问题所致。采用定量夹心酶联免疫吸附测定法检测TNF，该方法对血清中浓度大于或等于40 pg/mL的人TNF敏感。在所研究的19例患者的血清样本中未检测到TNF。
