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普通人群中儿童和青少年双相情感障碍的肥胖和超重:文献综述和荟萃分析。

Obesity and overweight among children and adolescents with bipolar disorder from the general population: A review of the scientific literature and a meta-analysis.

机构信息

Mood Instability Research Group, Centre for Psychiatry, Imperial College, London, UK.

Department of Psychiatry, University of Granada, Granada, Spain.

出版信息

Early Interv Psychiatry. 2022 Feb;16(2):113-125. doi: 10.1111/eip.13137. Epub 2021 Mar 18.

Abstract

There is substantial evidence of the high prevalence of obesity (OB) and overweight (OW) and their association with increased medical and psychiatric burden among adults with bipolar disorder (BD). However, little is known regarding its prevalence among young people with BD, other than the risk from psychotropic medication, which has been the focus of research in this population. We present a systematic review and meta-analysis of the literature on prevalence and correlates of OB and OW children and adolescents with BD using a different perspective than impact of medication. Four studies met inclusion criteria. The prevalence of OB in children and adolescents with BD was 15% (95% CI 11-20%). We observed a higher prevalence of OB in comparison to the general population. Different studies found significant associations between OB, OW, and BD in young populations including non-Caucasian race, physical abuse, suicide attempts, self-injurious behaviours, psychotropic medication, and psychiatric hospitalizations.

摘要

有大量证据表明,肥胖症(OB)和超重(OW)在双相情感障碍(BD)成年患者中普遍存在,并且与医疗和精神负担增加有关。然而,除了精神药物治疗的风险外,我们对青少年 BD 患者中肥胖症和超重症的患病率知之甚少,这一直是该人群研究的重点。我们使用与药物影响不同的视角,对双相情感障碍儿童和青少年肥胖症和超重症的患病率和相关因素进行了系统回顾和荟萃分析。四项研究符合纳入标准。患有 BD 的儿童和青少年中肥胖症的患病率为 15%(95%CI 11-20%)。我们观察到与普通人群相比,OB 的患病率更高。不同的研究发现,OB、OW 和 BD 之间存在显著关联,包括非白种人种族、身体虐待、自杀未遂、自残行为、精神药物治疗和精神病院住院治疗。

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