Department of Surgery, Kaifeng Central Hospital, Kaifeng, 475000, Henan Province, China.
Department of General Surgery, General Hospital of Xinjiang Military Command, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China.
BMC Gastroenterol. 2021 Mar 18;21(1):125. doi: 10.1186/s12876-021-01677-w.
This study was performed to understand the prevalence of and possible risk factors for cholecystolithiasis in Uyghur, Kazakh, Han, and other ethnic groups in the Xinjiang Uyghur autonomous region of China.
Subjects were enrolled using typical case sampling and multistage stratified random sampling. We collected epidemiological data regarding cholecystolithiasis using a standard questionnaire of risk factors for gallbladder disease in Xinjiang. The subjects completed the questionnaire and underwent an abdominal ultrasound examination of the liver and gallbladder.
This study included 5454 Xinjiang residents aged ≥ 18 years. The prevalence of cholecystolithiasis was 15% (11.3% in men and 17.1% in women), and the sex difference was statistically significant (male-to-female odds ratio [OR] 1.867; p < 0.001). The cholecystolithiasis prevalence was also significantly different among the Han, Uyghur, Kazakh, and other ethnic groups (13.1%, 20.8%, 11.5%, and 16.8%, respectively; p < 0.001). The prevalence of cholecystolithiasis in northern Xinjiang was 13.5% and that in southern Xinjiang was 17.5%; this difference was also statistically significant (OR 1.599; p < 0.001). Across all ethnic groups, the cholecystolithiasis prevalence significantly increased with age (all p < 0.01) and body mass index (BMI) (all p < 0.01). A multivariate logistic regression analysis indicated that cholecystolithiasis prevalence was associated with sex, age, BMI, smoking, diabetes, fatty liver disease, and geographical differences between northern and southern Xinjiang.
The prevalence of cholecystolithiasis was significantly higher in the Uyghur ethnic group than in the Han, Kazakh, and other ethnic groups; in women than in men; in southern Xinjiang than in northern Xinjiang; in patients with fatty liver disease; and increased with age and BMI. Our findings could provide a theoretical basis for the formulation of control measures for cholecystolithiasis.
本研究旨在了解中国新疆维吾尔自治区维吾尔族、哈萨克族、汉族和其他民族胆囊结石的流行情况及可能的危险因素。
采用典型病例抽样和多阶段分层随机抽样的方法，收集新疆胆囊疾病危险因素的标准问卷，了解胆囊结石的流行病学资料。研究对象完成问卷，并接受肝脏和胆囊的腹部超声检查。
本研究共纳入 5454 名年龄≥18 岁的新疆居民。胆囊结石的患病率为 15%（男性 11.3%，女性 17.1%），男女之间差异有统计学意义（男女性别比[OR] 1.867；p<0.001）。汉族、维吾尔族、哈萨克族和其他民族之间胆囊结石的患病率也有显著差异（分别为 13.1%、20.8%、11.5%和 16.8%；p<0.001）。新疆北部胆囊结石患病率为 13.5%，南部为 17.5%，差异有统计学意义（OR 1.599；p<0.001）。在所有民族中，胆囊结石的患病率随年龄（均 p<0.01）和体重指数（BMI）（均 p<0.01）的增加而显著增加。多因素 logistic 回归分析表明，胆囊结石的患病率与性别、年龄、BMI、吸烟、糖尿病、脂肪肝以及新疆南北部的地理差异有关。
维吾尔族胆囊结石的患病率明显高于汉族、哈萨克族和其他民族；女性高于男性；南部高于北部；在脂肪肝患者中更高；并随年龄和 BMI 的增加而增加。本研究结果可为制定胆囊结石防治措施提供理论依据。
