Department of Anesthesiology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiao Heyan Road, Shenyang, 110042, China.
Syst Rev. 2021 Mar 18;10(1):79. doi: 10.1186/s13643-021-01610-y.
Postoperative cognitive dysfunction (POCD) is a common condition after general anesthesia (GA). Previous studies have reported that propofol can ameliorate the occurrence of such disorder. However, its results are still inconsistent. Therefore, this systematic review will assess the efficacy and safety of propofol on POCD after GA.
Literature sources will be sought from inception to the present in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Web of Science, Scopus, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for randomized controlled trials (RCTs) assessing the administration of propofol on POCD after GA. All searches will be carried out without limitations to language and publication status. Outcomes comprise of cognitive impairments changes, impairments in short-term memory, concentration, language comprehension, social integration, quality of life, and adverse events. Cochrane risk of bias tool will be utilized to assess study quality. We will evaluate the quality of evidence for each outcome using Grading of Recommendations Assessment, Development and Evaluation approach. A narrative synthesis or a meta-analysis will be undertaken as appropriate.
This study will systematically and comprehensively search literature and integrate evidence on the efficacy and safety of propofol on POCD after GA. Our findings will be of interest to clinicians and health-related policy makers.
PROSPERO CRD42020164096.
全身麻醉（GA）后认知功能障碍（POCD）是一种常见情况。先前的研究报告表明，丙泊酚可以改善这种疾病的发生。然而，其结果仍不一致。因此，本系统评价将评估 GA 后丙泊酚对 POCD 的疗效和安全性。
从 Cochrane 图书馆、MEDLINE、EMBASE、PsycINFO、Web of Science、Scopus、辅助和补充医学数据库、中国生物医学文献数据库和中国国家知识基础设施中，检索到评估 GA 后给予丙泊酚对 POCD 影响的随机对照试验（RCT）的文献。所有搜索均不限制语言和出版状态。结局包括认知功能障碍的变化、短期记忆、注意力、语言理解、社会融合、生活质量和不良事件。Cochrane 偏倚风险工具将用于评估研究质量。我们将使用推荐评估、制定和评估方法（Grading of Recommendations Assessment, Development and Evaluation approach）评估每个结局的证据质量。将根据情况进行叙述性综合或荟萃分析。
本研究将系统全面地检索文献，并综合 GA 后丙泊酚对 POCD 的疗效和安全性的证据。我们的研究结果将引起临床医生和与健康相关的政策制定者的兴趣。
PROSPERO CRD42020164096。
