Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Trends Pharmacol Sci. 2021 Jun;42(6):426-428. doi: 10.1016/j.tips.2021.03.001. Epub 2021 Mar 15.
Apparent blood-brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
血脑屏障（BBB）破坏在胶质母细胞瘤（GBM）中很常见，但并未转化为改善药物递送效果。最近，de Gooijer 等人表明，外排转运体在限制药物递送到肿瘤细胞中可能起着重要作用。这些转运系统导致药物在脑内肿瘤细胞中的递送效果不佳。
