尽管血脑屏障被破坏，但外排限制了肿瘤的药物递送。
Efflux Limits Tumor Drug Delivery Despite Disrupted BBB.
机构信息
Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
出版信息
Trends Pharmacol Sci. 2021 Jun;42(6):426-428. doi: 10.1016/j.tips.2021.03.001. Epub 2021 Mar 15.
Apparent blood-brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
血脑屏障（BBB）破坏在胶质母细胞瘤（GBM）中很常见，但并未转化为改善药物递送效果。最近，de Gooijer 等人表明，外排转运体在限制药物递送到肿瘤细胞中可能起着重要作用。这些转运系统导致药物在脑内肿瘤细胞中的递送效果不佳。
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