Department of Urology, University of Vienna, Vienna, Austria; Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.
Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.
Eur Urol Focus. 2022 Mar;8(2):580-587. doi: 10.1016/j.euf.2021.03.010. Epub 2021 Mar 16.
The association between total and truncal body fat and kidney stone (KS) remains unclear.
To evaluate the association between total and truncal body fat and KS in the US adult population.
DESIGN, SETTING, AND PARTICIPANTS: The National Health and Nutrition Examination Survey (NHANES) comprises a series of nationally representative cross-sectional surveys. Data from females and males aged 20-59 yr who participated in four 2-yr NHANES cycles between 2011 and 2018 were obtained.
Multivariable-adjusted logistic regression models were used to investigate the association between dual-energy x-ray absorptiometry (DXA) scan-measured total and truncal body fat percentage and mass with KS.
A total of 10 271 participants (50.3% females) were included. Weighted KS prevalence was 8.11% in femalesand 7.55% in males. In males, higher fat percentage was associated with higher odds of KS (per 5% total fat: odds ratio [OR] = 1.19, 95% confidence interval [CI] 1.08-1.32; per 5% truncal fat: OR = 1.22, 95% CI 1.10-1.35), particularly in those aged 40-59 yr (per 5% total fat: OR = 1.36, 95% CI 1.16-1.59; per 5% truncal fat: OR = 1.41, 95% CI 1.20-1.65, p-interaction < 0.05). In females, higher fat percentage was associated with higher odds of KS overall (per 5% total fat: OR = 1.23, 95% CI 1.10-1.37; per 5% truncal fat: OR = 1.20, 95% CI 1.08-1.33) and in both age groups (20-39 and 40-59 yr, p-interaction > 0.05). The observed associations were stronger in "other" ethnicities and non-Hispanic white. Similar patterns were observed for per 5 kg body fat mass.
Total and truncal fat parameters are associated with a higher prevalence of KS in adult females and males who are ≥40 yr old. Truncal fat mass may be at least equal or superior to total fat mass in assessing the association of body fat with KS. Further studies are warranted to elaborate on the pathophysiologic mechanism of this association to decrease the prevalence of KS.
Total and truncal body fat are associated with a higher prevalence of kidney stone (KS) in adult females and males aged ≥40 yr. Truncal fat mass may be similar or superior to total fat mass in assessing the association between body fat and KS.
全身和躯干部脂肪与肾结石（KS）之间的关联仍不清楚。
评估美国成年人全身和躯干部脂肪与 KS 之间的关联。
设计、地点和参与者：国家健康和营养检查调查（NHANES）包括一系列具有全国代表性的横断面调查。我们获得了 2011 年至 2018 年期间参加了四个 2 年 NHANES 周期的 20-59 岁女性和男性的数据。
使用多变量调整的 logistic 回归模型来研究双能 X 射线吸收仪（DXA）扫描测量的全身和躯干部脂肪百分比和质量与 KS 之间的关联。
共纳入 10271 名参与者（50.3%为女性）。女性 KS 的加权患病率为 8.11%，男性为 7.55%。在男性中，较高的脂肪百分比与 KS 的几率增加相关（每 5%全身脂肪：比值比[OR] = 1.19，95%置信区间[CI] 1.08-1.32；每 5%躯干部脂肪：OR = 1.22，95% CI 1.10-1.35），尤其是在 40-59 岁的人群中（每 5%全身脂肪：OR = 1.36，95% CI 1.16-1.59；每 5%躯干部脂肪：OR = 1.41，95% CI 1.20-1.65，p 交互 < 0.05）。在女性中，较高的脂肪百分比与 KS 的几率增加相关（每 5%全身脂肪：OR = 1.23，95% CI 1.10-1.37；每 5%躯干部脂肪：OR = 1.20，95% CI 1.08-1.33），并且在两个年龄组（20-39 岁和 40-59 岁，p 交互 > 0.05）中均如此。在“其他”种族和非西班牙裔白人中观察到的关联更强。每 5 公斤体脂质量也表现出类似的模式。
全身和躯干部脂肪参数与≥40 岁的成年女性和男性中 KS 的更高患病率相关。在评估体脂与 KS 的关联时，躯干部脂肪质量可能与全身脂肪质量相当或更优。需要进一步的研究来阐述这种关联的病理生理机制，以降低 KS 的患病率。
全身和躯干部脂肪与≥40 岁的成年女性和男性 KS 的更高患病率相关。在评估体脂与 KS 的关联时，躯干部脂肪质量可能与全身脂肪质量相当或更优。
