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运动、睡眠和饮食对老年人轻度创伤性脑损伤后神经认知康复的影响:叙事性综述。

The impact of exercise, sleep, and diet on neurocognitive recovery from mild traumatic brain injury in older adults: A narrative review.

机构信息

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South St, Murdoch, Western Australia, Australia; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute Building, 8 Verdun St, Nedlands, Western Australia, Australia.

Curtin Health Innovation Research Institute, Sarich Neuroscience Research Institute Building, 8 Verdun St, Nedlands, Western Australia, Australia; Perron Institute for Neurological and Translational Science, Sarich Neuroscience Research Institute Building, 8 Verdun St, Nedlands, Western Australia, Australia; School of Biological Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, Australia.

出版信息

Ageing Res Rev. 2021 Jul;68:101322. doi: 10.1016/j.arr.2021.101322. Epub 2021 Mar 15.

Abstract

Mild traumatic brain injury (mTBI) accounts for a large majority of traumatic brain injuries sustained globally each year. Older adults, who are already susceptible to age-related declines to neurocognitive health, appear to be at an increased risk of both sustaining an mTBI and experiencing slower or impaired recovery. There is also growing evidence that mTBI is a potential risk factor for accelerated cognitive decline and neurodegeneration. Lifestyle-based interventions are gaining prominence as a cost-effective means of maintaining cognition and brain health with age. Consequently, inter-individual variations in exercise, sleep, and dietary patterns could influence the trajectory of post-mTBI neurocognitive recovery, particularly in older adults. This review synthesises the current animal and human literature centred on the mechanisms through which lifestyle-related habits and behaviours could influence acute and longer-term neurocognitive functioning following mTBI. Numerous neuroprotective processes which are impacted by lifestyle factors have been established in animal models of TBI. However, the literature is characterised by a lack of translation to human samples and limited appraisal of the interaction between ageing and brain injury. Further research is needed to better establish the therapeutic utility of applying lifestyle-based modifications to improve post-mTBI neurocognitive outcomes in older adults.

摘要

轻度创伤性脑损伤(mTBI)占全球每年发生的创伤性脑损伤的绝大多数。老年人已经容易受到与年龄相关的神经认知健康下降的影响,他们似乎面临更高的风险,无论是遭受 mTBI 还是经历更慢或受损的恢复。越来越多的证据表明,mTBI 是加速认知能力下降和神经退行性变的潜在风险因素。基于生活方式的干预措施作为一种具有成本效益的方法,越来越受到关注,可以随着年龄的增长保持认知和大脑健康。因此,运动、睡眠和饮食模式的个体差异可能会影响 mTBI 后神经认知恢复的轨迹,特别是在老年人中。这篇综述综合了当前以动物和人类为中心的文献,这些文献集中在与生活方式相关的习惯和行为如何影响 mTBI 后的急性和长期神经认知功能的机制上。大量已在创伤性脑损伤动物模型中确定的神经保护过程受到生活方式因素的影响。然而,文献的特点是缺乏向人类样本的转化,并且对衰老和脑损伤之间的相互作用的评估有限。需要进一步的研究来更好地确定应用基于生活方式的改变来改善老年人 mTBI 后神经认知结果的治疗效果。

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