Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Emergency Medicine Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Sci Rep. 2021 Mar 18;11(1):6350. doi: 10.1038/s41598-021-85788-0.
We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
我们通过气相色谱-质谱联用技术鉴定了与重症（n=46）和轻症（n=19）COVID-19 患者相关的血清代谢物的主要变化。在缺氧条件下，改变的代谢谱与氨基酸分解代谢有关。值得注意的是，三种氨基酸来源的α-羟基酸随着疾病的严重程度而增加，与氧饱和度的改变和肺部损伤的临床标志物相关。我们假设α-酮酸向α-羟基酸的酶促转化有助于在氧水平改变的患者中维持 NAD 循环，这突出了在 SARS-CoV-2 感染期间补充氨基酸的潜在相关性。
