Qi Licui, Kang Ning, Li Yong, Zhao Hang, Chen Shuchun
Graduate School of Hebei North University, Zhangjiakou, 075000, People's Republic of China.
Endocrinology Department, Hebei General Hospital, Shijiazhuang, 050051, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Mar 11;14:1107-1115. doi: 10.2147/DMSO.S302761. eCollection 2021.
This study aims to investigate the predictive value of visceral adiposity index (VAI) and lipid accumulation index (LAP) for microalbuminuria (MAU) in patients with newly diagnosed Type 2 diabetes (T2DM).
This study included 335 patients with newly diagnosed T2DM patients from Hebei General Hospital. All the patients aged from 18 to 65 years old include 226 males and 109 females. Patients information and blood indicators were Collected and calculated the LAP and VAI scores. All the patients were divided into males (group A) and females (group B), and these groups were then further subdivided into A1 group which arises microalbuminuria, and A2 group which does not. With the same method, women were divided into B1 group and B2 group.
Baseline data analysis showed that LAP and VAI levels in A1 and B1 groups were significantly higher than those in A2 and B2 groups (P<0.05). Logistic regression analysis showed that fasting blood glucose, waist circumference, LAP, and VAI were independent risk factors for the occurrence of microalbuminuria in both males and females. ROC showed that the area under curve (AUC) of waist circumference, fasting blood glucose, LAP and VAI in male patients were 0.626, 0.676, 0.760 and 0.742, respectively, and in female patients were 0.703, 0.685, 0.787 and 0.764, respectively. In addition, the area under the curve of both LAP and VAI was higher in females than in males.
This study confirmed that both LAP and VAI had predictive values for the occurrence of urinary microalbumin in newly diagnosed T2DM patients. The predictive value was higher in the female group and the suggestion was more applicable to female patients.
本研究旨在探讨内脏脂肪指数(VAI)和脂质蓄积指数(LAP)对新诊断2型糖尿病(T2DM)患者微量白蛋白尿(MAU)的预测价值。
本研究纳入了河北医科大学第二医院335例新诊断的T2DM患者。所有患者年龄在18至65岁之间,其中男性226例,女性109例。收集患者信息和血液指标,并计算LAP和VAI评分。所有患者分为男性组(A组)和女性组(B组),然后将这些组进一步细分为出现微量白蛋白尿的A1组和未出现微量白蛋白尿的A2组。采用相同方法,女性分为B1组和B2组。
基线数据分析显示,A1组和B1组的LAP和VAI水平显著高于A2组和B2组(P<0.05)。Logistic回归分析显示,空腹血糖、腰围、LAP和VAI是男性和女性发生微量白蛋白尿的独立危险因素。ROC曲线显示,男性患者腰围、空腹血糖、LAP和VAI的曲线下面积(AUC)分别为0.626、0.676、0.760和0.742,女性患者分别为0.703、0.685、0.787和0.764。此外,LAP和VAI的曲线下面积在女性中高于男性。
本研究证实,LAP和VAI对新诊断T2DM患者尿微量白蛋白的发生均具有预测价值。女性组的预测价值更高,该建议更适用于女性患者。